Publication: Effects of triple treatment with
octreotide, galanin and serotonin on a
human pancreas cancer cell line in xenografts
Authors
El-Salhy, M. ; Tjomsland, V. ; Theodorsson, E.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Human pancreas cancer cells were implanted
s.c. in nude mice. After 11 days, the mice were divided
into two groups of 13. The first group received sterile
saline solution and the second received triple therapy
containing octreotide, galanin and serotonin, 40
µg/kg/day as a continuous i.p. infusion via an implanted
osmotic pump for 14 days. Triple therapy prolonged the
survival rate of the mice bearing human pancreatic
carcinoma. Both the volume and weight of tumours in
mice given triple therapy were less than in controls (not
statistically significant). The proliferation index and the
labelling index for epidermal growth factor (EGF)
increased significantly in mice given triple therapy vis-ávis
controls. There was no statistically significant
difference between control and treated tumours as
regards, apoptotic index, necrosis, or number of tumour
blood vessels. The increased survival rate was attributed
to the reduced tumour load, since both weight and
volume were reduced. It is most probable that octreotide
was the responsible agent. Further investigation with
single and double combinations of octreotide, galanin
and serotonin are needed to identify the cause of
increased cell proliferation in tumours subjected to these
bioactive substances. Identifying the agent(s) inducing
pancreatic cancer cell proliferation may be useful in
combining a new treatment, as antagonists to these
bioactive substances are available.
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