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Dietary Patterns in Pregnancy and Biomarkers of Oxidative Stress in Mothers and Offspring: The NELA Birth Cohort

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dc.contributor.authorMorales, Eva
dc.contributor.authorGarcía-Serna, Azahara M.
dc.contributor.authorLarqué, Elvira
dc.contributor.authorSánchez-Campillo, María
dc.contributor.authorSerrano-Munera, Ana
dc.contributor.authorMartinez-Graciá, Carmen
dc.contributor.authorSuárez-Martínez, Clara
dc.contributor.authorVioque, Jesús
dc.contributor.authorBallesteros-Meseguer, Carmen
dc.contributor.authorGaldo-Castiñeira, Lina
dc.contributor.authorGarcía-Marcos, Luis
dc.contributor.authorSantaella-Pascual, Marina
dc.contributor.authorAvilés Plaza, Francisco Valeriano
dc.contributor.authorMartínez Villanueva, Miriam
dc.contributor.authorNoguera Velasco, José Antonio
dc.contributor.departmentCiencias Sociosanitarias
dc.date.accessioned2024-01-31T08:22:26Z
dc.date.available2024-01-31T08:22:26Z
dc.date.issued2022-04
dc.description©<2022>. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Published, version of a Published Work that appeared in final form in Frontiers in nutrition. To access the final edited and published work see https://doi.org/10.3389/fnut.2022.869357
dc.description.abstractBackground: Although adherence to the Mediterranean and antioxidant-rich diets during pregnancy is suggested to improve maternal-fetal health by reducing oxidative stress, yet there is no study available. Objective: We examined whether maternal dietary patterns in pregnancy impact the biomarkers of oxidative stress in mothers and their offspring. Methods: Study population included 642 mothers and 335 newborns of the "Nutrition in Early Life and Asthma" (NELA) birth cohort. Maternal diet during pregnancy was assessed by a validated food frequency questionnaire and a priori-defined dietary indices (relative Mediterranean Diet [rMED], alternative Mediterranean Diet [aMED], Dietary Approach to Stop Hypertension [DASH], Alternate Healthy Index [AHEI], and AHEI-2010) were calculated. Biomarkers measured were: hydroperoxides, carbonyl groups, and 8-hydroxydeoxyguanosine (8OHdG) determined in maternal blood and newborn cord blood, and urinary maternal and offspring 15-F2t-isoprostane. Multivariate linear regression models were performed. Results: Maternal rMED score was inversely associated with the maternal levels of 8OHdG at mid-pregnancy (beta per 1-point increase = -1.61; 95% CI -2.82, -0.39) and the newborn levels of hydroperoxides (beta per 1-point increase = -4.54; 95% CI -9.32, 0.25). High vs. low maternal rMED score was marginally associated with the decreased levels of 8OHdG in newborns (beta = -9.17; 95% CI -19.9, 1.63; p for trend 0.079). Maternal DASH score tended to be inversely associated with maternal urinary 15-F2t-isoprostane (beta per 1-point increase = -0.69; 95% CI, -1.44, 0.06). High vs. low maternal AHEI score was associated with reduced offspring urinary levels of 15-F2t-isoprostane (beta = -20.2; 95% CI -38.0, -2.46; p for trend 0.026). Conclusion: These results suggest that maternal adherence to healthy dietary patterns during pregnancy may reduce DNA damage and lipid oxidation in mothers and offspring.es
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dc.identifier.citationFrontiers in Nutrition, Sec. Nutritional Epidemiology Volume 9 - 2022
dc.identifier.doi10.3389/fnut.2022.869357
dc.identifier.urihttp://hdl.handle.net/10201/138224
dc.languageenges
dc.relationInstituto de Salud Carlos III, Spanish Ministry of Science, Innovation and Universities, and co-funded by the European Union (Grant Numbers: CP14/00046, PIE15/00051, PI16/00422, PI19/00863, and ARADyAL network RD160006). AG-S was funded by a predoctoral Fellowship (FI17/00086) and EM was funded by Miguel Servet Fellowships (MS14/00046 and CPII19/00019) awarded by the Instituto de Salud Carlos III (ISCIII), Spanish Ministry of Science, Innovation and Universities, and Fondos FEDER.es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleDietary Patterns in Pregnancy and Biomarkers of Oxidative Stress in Mothers and Offspring: The NELA Birth Cohortes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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relation.isAuthorOfPublication78abb44c-db12-4773-ae35-2608e3f81343
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