Publication: MlBl proliferation index in breast infiltrating carcinoma: Comparison with other proliferative markers and
association with new biological prognostic factors
Authors
González-Vela, M.C. ; Garijo, M.F. ; Fernández, F. ; Val-Bernal, José Fernando
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Aims: In breast invasive carcinoma our
objectives were 1) to compare cellular proliferation
determined by MIBl index with S-phase fraction (SPF)
assessed by flow cytometry and with mitotic index, and
11) to examine the association of MIBl index with
classical and with new biological prognostic factors [bcl-
2, p53, c-erbB-2 and cathepsin D (CD)]. Methods and
results: From 102 cases of breast invasive carcinoma, 5-
pm thick serial sections were cut from formalin-fixed,
paraffin-embedded tissue blocks, and processed for
detection of CD, c-erbB-2, p53, bcl-2, Ki-67 antigen
MIB-1 and estrogen receptors (ER) and progesterone
receptors (PR). SPF was measured by flow cytometry in
fresh-frozen tissue samples taken from the carcinoma in
each patient. MIBl index was correlated with SPF
(rho=0.45, pe0.0001) and with mitotic index (rho=0.42,
p<0.0001). The MIB-1 index was positively associated
with the histological grade (p=0.001), tumor size
(p=0.04) and the presence of metastases in axillary
lymph nodes (p=0.01). MIBl was associated directly
with p53 @=0.045) and inversely with bcl-2 @=0.0002).
The MIB-1 index was not statistically associated with cerbB-
2. There was a weak association between MIBl
index and stromal cell CD. The median MIBl index was
higher in tumors with moderate to strong CD staining of
stromai cell, but the difference did not reach statistical significance (p=0.09). Conclusions: MIBl index
correlates with well established methods for assessing
tumor proliferation and with parameters of an aggressive
phenotype of tumor. MIBl index is an effective and
readily accessible method for assessing tumor
proliferation in breast carcinoma.
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