The efficacy of a deproteinized bovine bone mineral graft for alveolar ridge preservation: a histologic study in humans

Sánchez Pérez, Arturo; Rodríguez-Sánchez, Marcos; Jornet García, Alfonso; Moya Villaescusa, María José; Martínez Cáceres, Carlos Manuel

Publication:
The efficacy of a deproteinized bovine bone mineral graft for alveolar ridge preservation: a histologic study in humans

dc.contributor.author	Sánchez Pérez, Arturo
dc.contributor.author	Rodríguez-Sánchez, Marcos
dc.contributor.author	Jornet García, Alfonso
dc.contributor.author	Moya Villaescusa, María José
dc.contributor.author	Martínez Cáceres, Carlos Manuel
dc.contributor.department	Dermatología, Estomatología, Radiología y Medicina Física	es
dc.date.accessioned	2025-06-17T07:22:40Z
dc.date.available	2025-06-17T07:22:40Z
dc.date.created	2025-05-31
dc.description	© 2025, by the authors. Licensee MDPI, Basel, Switzerland. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/. This document is the Published version of a Published Work that appeared in final form in Biomedicines. To access the final edited and published work see https://doi.org/10.3390/biomedicines13061358
dc.description.abstract	Background: Alveolar ridge preservation (ARP) following tooth extraction plays a vital role in maintaining ridge dimensions and supporting subsequent implant therapy. Objectives: This study histologically and radiographically evaluates the efficacy of techBiomat bone®—a deproteinized bovine bone mineral (DBBM)—for alveolar ridge preservation (ARP), comparing the results of bone formation, residual graft particles, and nonmineralized tissue to those of spontaneous healing in human tooth sockets. Methods: A split-mouth study was conducted to evaluate the radiographic and histologic outcomes in human sockets with and without ARP. Results: A significant improvement in bone fill was observed compared to untreated sockets. Radiographically, 87% of the treated sockets demonstrated more than 75% bone fill, whereas only 7% of the untreated sockets did. Histologically, the percentage of new bone formation was greater in treated sockets (42%) than in untreated sockets (25%). The findings also highlighted a lower proportion of nonmineralized tissue in grafted sites, suggesting improved healing over spontaneous healing. The residual graft material in the treated sockets had a moderate resorption rate, with almost complete replacement by the host bone after six months. The use of techBiomat bone® demonstrated promising results, with a resorption rate conducive to optimal bone regeneration, with less than 9% residual graft material remaining after six months. Conclusions: This study supports the efficacy of techBiomat bone® graft material for ARP, highlighting its potential in maintaining ridge volume. Further studies with larger sample sizes are needed to confirm these findings.	es
dc.format	application/pdf	es
dc.format.extent	15	es
dc.identifier.citation	Biomedicines 2025,13,1358
dc.identifier.doi	https://doi.org/10.3390/biomedicines13061358
dc.identifier.issn	Electronic: 2227-9059
dc.identifier.uri	http://hdl.handle.net/10201/156240
dc.language	eng	es
dc.publisher	MDPI
dc.relation	This research was supported by external funding through a research contract between the Research Transfer Office (OTRI) at the University of Murcia and Technology In Biomaterials, S.L. The contract is titled PMCF-TECHBIOMATBONE and is associated with project code 36783.	es
dc.relation.publisherversion	https://www.mdpi.com/2227-9059/13/6/1358
dc.rights	info:eu-repo/semantics/openAccess	es
dc.rights	Atribución 4.0 Internacional	*
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	*
dc.subject	Tooth loss	es
dc.subject	Alveolar process
dc.subject	Alveolar bone atrophy
dc.subject	Alveolar bone loss
dc.subject	Bone remodeling
dc.subject	Alveolar ridge preservation
dc.subject	Alveolar bone grafting
dc.title	The efficacy of a deproteinized bovine bone mineral graft for alveolar ridge preservation: a histologic study in humans	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es
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