Publication: Electron microscopic study on amyloid fibril formation in human lymph nodes
Loading...
Date
1986
Authors
Michio Dobashi ; Fumiaki Yuda ; Akihiro Masuda ; Kazuo Terashima ; Yutaka lmai
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
The purpose of this investigation was to clarify
the mechanisms of amyloid fibril formation in human
lymph nodes. In our present study, amyloid deposition was
observed diffusely in all compartments of the lymph nodes.
The deposition form showed extremely characteristic
findings in its morphological features. Namely, amyloid
deposits mainly consisted of clusters of round or oval
nodules. Each amyloid nodule was frequently enclosed with
long-stretched cytoplasmic processes of abutting reticulum
cells and/or macrophages. Amyloid fibrils often formed
parallel amyloid bundles radiating to outlying sections of
the nodule from the center. The amyloid bundles closely
adhered to the cytoplasmic membrane of not only the
abutting reticulum cells, macrophages and sinus
endothelium but also to the lymphocytes and plasma cells.
In the central portion of the amyloid nodules, a concentric
core was also observed.
The most interesting finding was the intracellular
formation of amyloid fibrils in all cells, such as
macrophages, reticulum cells, foreign body giant cells and
lymphocytes in the process of degeneration. Some fibrils
localized in the limited area of the cytoplasm and others
appeared in all parts of the cells, including the nucleus.
Their cell membranes were missing in several areas and the
cell organella had gradually dissolved. Finally the cell
residuums were completely replaced by amyloid fibrils and
transformed into a nodular structure with radiating bundles
of amyloid fibrils.
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.