Publication: Histomorphological analysis of human cranial bones: Relationship to aging
Authors
Pasuk Mahakkanukrauh ; Treerat Gumpangseth
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Publisher
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Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/10.14670/HH-25-012
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info:eu-repo/semantics/article
Description
Abstract
Aging induces alterations in bone
microarchitecture, including bone function. This study
aimed to identify histological changes in the components
of cranial bones of the human skull and to investigate
their relationship with aging. In this study, sixty-four
fresh cranial remains were examined with an age range
of 43-90 years, the crania being randomly selected to
investigate the microstructure of the frontal, temporal,
parietal, and occipital bones, which were stained using
picrosirius red. Our results observed similar histological
changes in the frontal, temporal, parietal, and occipital
bones. Results of the histomorphological analyses
demonstrated that there was an age-related gradual
increase in the number of osteons. A distinct increase in
the number of osteons in the cortical bone was found,
particularly over 60 years. As age increased, the area of
the circumferential lamellae adjacent to the periosteum
also tended to diminish. A greater lamellar area was
found in association with younger individuals, the area
declining with age. In some samples from individuals
older than 80 years, the outer circumferential lamellae
were no longer visible. In addition, there was an
association between cortical porosity and numbers, and
the enlargement of porosity and age. The size of the
pores in the cancellous bone tended to increase as well.
This histomorphological study increases the
comprehension regarding the relationship between the
aging process and the structure of the human cranial
bone in adults, and the results can be regarded as
alternative data in the determination of age in humans.
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