Publication: The hepatic stellate cell in the post-genomic era
Authors
Okuyama, H. ; Shimahara, Y. ; Kawada, N.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The draft human genome sequence was
published on February 15, 2001, which will provide a
huge amount of information on human genetics, human
disease, and human cell biology. Now, medical scientists
and cell biologists are turning their attention to
illustrating gene expression pattern using gene
microarray and to identifying the functions and the
expression patterns of proteins encoded by the genes.
Hepatic stellate cell is one of the sinusoidconstituent
cells that play multiple roles in the liver
p a t h o p h y s i o l o g y. Transformation of stellate cells from
the vitamin A-storing phenotype to the
“myofibroblastic” one closely correlates to hepatic
fibrosis during chronic liver trauma. Analyses of the
molecular mechanisms of stellate cell activation have
made a great progress, in particular, in the field of
intracellular signal transduction of transforming growth
f a c t o r-ß and platelet-derived growth factor, integrin
signaling related to cell-adhesion, and cell motilityassociated
Rho and focal-adhesion kinase. Accumulation
of the information on the stellate cell activation would
shed light on the establishment of a novel therapeutic
strategy against fibrosis of human liver disease.
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