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The effects of PSK, a biological response

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dc.contributor.authorMatsui, H.es
dc.contributor.authorSetogawa, T.es
dc.contributor.authorTanaka, Osamu
dc.date.accessioned2011-02-22T10:29:35Z
dc.date.available2011-02-22T10:29:35Z
dc.date.issued1995
dc.description.abstractThe antiteratogenic effects of PSK, a biological response modifier, were examined using histological and developmental analysis. The whole bodies of pregnant mice were irradiated with X-rays and injected with PSK within ten minutes after irradiation on day 7 of gestation (E7). The foetuses on E18 were examined and a high incidence of malformations were observed in X-ray irradiated embryos. Microphthalmia was the most frequent malformation. PSK administration suppressed the X-ray irradiation-induced ocular anomalies in not only the frequency, as deduced by external observation. but also in histopathological changes in the retina, lens, and cornea. In particular. the incidence of lens aplasia was significantly decreased by PSK administration. Developmental analysis using E10 and E13 embryos revealed that the decrease in the incidence of histopathological changes was first observed within 72 hours after PSK administration. In addition, X-ray irradiation-induced early foetal death (E 1 O- 13) was also suppressed by PSK administration. The possible mechanisms of the antiteratogenic effects of PSK are discussed.es
dc.formatapplication/pdfes
dc.format.extent8es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/18705
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectMicrophthalmiaes
dc.subjectAntiteratogenes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleThe effects of PSK, a biological responsees
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.10, nº 1 (1995)