Publication:
Air pollution from traffic during pregnancy impairs newborn's cord blood immune cells: The NELA cohort

Simple item page
dc.contributor.authorGarcía-Serna, Azahara M
dc.contributor.authorJiménez-Guerrero, Pedro
dc.contributor.authorPérez-Fernández, Virginia
dc.contributor.authorCantero-Cano, Esther
dc.contributor.authorMuñoz-García, María
dc.contributor.authorBallesteros-Meseguer, Carmen
dc.contributor.authorPérez de los Cobos, Irene
dc.contributor.authorGarcía-Marcos, Luis
dc.contributor.authorMorales, Eva
dc.contributor.authorHernández Caselles, Trinidad
dc.contributor.authorMartín-Orozco Santiago, María Elena
dc.contributor.departmentBioquímica y Biología Molecular B e Inmunología
dc.date.accessioned2024-01-28T13:52:58Z
dc.date.available2024-01-28T13:52:58Z
dc.date.issued2020-11-17
dc.description©2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Accepted version of a Published Work that appeared in final form in Environmental Research. To access the final edited and published work see https:// doi.org/10.1016/j.envres.2020.110468es
dc.description.abstractBackground: Hazards of traffic-related air pollution (TRAP) on the developing immune system are poorly understood. We sought to investigate the effects of prenatal exposure to TRAP on cord blood immune cell distributions; and to identify gestational windows of susceptibility. Methods: In-depth immunophenotyping of cord blood leukocyte and lymphocyte subsets was performed by flow cytometry in 190 newborns embedded in the Nutrition in Early Life and Asthma (NELA) birth cohort (2015-2018). Long-term (whole pregnancy and trimesters) and short-term (15-days before delivery) residential exposures to traffic-related nitrogen dioxide (NO2), particulate matter (PM2.5 and PM10), and ozone (O3) were estimated using dispersion/chemical transport modelling. Associations between TRAP concentrations and cord blood immune cell counts were assessed using multivariate Poisson regression models. Results: Mean number of natural killer (NK) cells decreased 15% in relation to higher NO2 concentrations (≥36.4 μg/m3) during whole pregnancy (incidence relative risk (IRR), 0.85; 95% CI, 0.72, 0.99), with stronger associations in the first trimester. Higher PM2.5 concentrations (≥13.3 μg/m3) during whole pregnancy associated with a reduced mean number of cytotoxic T cells (IRR, 0.88; 95% CI, 0.78, 0.99). Newborns exposed to higher PM10 (≥23.6 μg/m3) and PM2.5 concentrations during the first and third trimester showed greater mean number of helper T type 1 (Th1) cells (P < 0.05). Decreased number of regulatory T (Treg) cells was associated with greater short-term NO2 (IRR, 0.90; 95% CI, 0.80, 1.01) and PM10 (IRR, 0.88; 95% CI, 0.77, 0.99) concentrations. Conclusions: Prenatal exposure to TRAP, particularly in early and late gestation, impairs fetal immune system development through disturbances in cord blood leukocyte and lymphocyte distributions.es
dc.formatapplication/pdfes
dc.format.extent10es
dc.identifier.citationEnvironmental Research 198 (2021) 110468
dc.identifier.doidoi.org/10.1016/j.envres.2020.110468
dc.identifier.issn0013-9351
dc.identifier.urihttp://hdl.handle.net/10201/137884
dc.languageenges
dc.relationThis study was supported by grants from Instituto de Salud Carlos III, Spanish Ministry of Science, Innovation and Universities, and Fondos FEDER (grant numbers CP14/00046, PIE15/00051, PI16/00422 and ARADyAL network RD160006). AMGS was funded by a predoctoral Fellowship (FI17/00086) and EM was funded by Miguel Servet Fellowships (MS14/00046 and CPII19/00019) awarded by the Instituto de Salud Carlos III, Spanish Ministry of Science, Innovation and Universities, and Fondos FEDERes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAir pollutiones
dc.subjectCord bloodes
dc.subjectImmune systemes
dc.subjectLeukocyteses
dc.subjectLymphocyteses
dc.subjectTraffices
dc.titleAir pollution from traffic during pregnancy impairs newborn's cord blood immune cells: The NELA cohortes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
relation.isAuthorOfPublicationc0416b92-3bd1-4c0a-bd7c-df5ae58f3f63
relation.isAuthorOfPublication24de46e8-df34-4c71-a701-2a30b079b958
relation.isAuthorOfPublication.latestForDiscoveryc0416b92-3bd1-4c0a-bd7c-df5ae58f3f63
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Garcia_Serna A et al 2020_EnvironmentalRes.pdf
Size:
2.4 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
2.26 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Artículos