Publication: Ferroportin is expressed on the
mucous granule membrane of a subpopulation
of goblet cells in the duodenum of the rat
Authors
Oates, P.S. ; Thomas, C.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Ferroportin is a basolateral transporter
involved in the release of iron from cells. In addition to
expression on the basolateral membrane of enterocytes,
ferroportin is also seen on the microvillus membrane.
This led us to consider that ferroportin might be
expressed by other cells of the intestine where it
contributes to iron metabolism. Ferroportin gene and
protein expression in rat duodenum was studied by in
situ hybridisation and immunohistochemistry,
respectively in rats with different efficiencies of iron
absorption. Ferroportin mRNA localised to enterocytes
of the villus only. Ferroportin was demonstrated in
enterocytes and in 30% of goblet cells. In goblet cells it
localised to the mucous granule membrane. In ironloaded
intestine some goblet cells contained iron
suggesting that ferroportin may transport iron into the
mucous granule where it would be lost during discharge
of mucous. The finding of ferroportin in iron deficient
goblet cells also suggests an additional role to iron
excretion.
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Citation
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