Publication: Atrophic hepatocytes express keratin 7 in ischemia-associated liver lesions
Authors
Delladetsima, Ioanna ; Sakellariou, Stratigoula ; Kokkori, Aikaterini ; Tiniakos, Dina
item.page.secondaryauthor
item.page.director
Publisher
Universidad de Murcia. Departamento de Biología Celular e Histología
publication.page.editor
publication.page.department
DOI
DOI: 10.14670/HH-11-738
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Aim: To investigate atrophic parenchymal
changes in ischemic liver conditions. Design: We studied
18 cases of hepatic lesions with atrophic changes due to
altered blood flow (hepatic venous congestion n=15
including 4 cases with additional nodular regenerative
hyperplasia-NRH, NRH n=1, and antiphospholipid
syndrome with patchy parenchymal atrophy n=2).
Metaplastic hepatocellular changes, hepatocyte
proliferation, hepatic stellate cell (HSC) activation, and
sinusoidal capillarization were examined immunohistochemically with antibodies to keratins (K) 7 and 19,
Ki67, αSMA and CD34, respectively. Results: K7 was
positive and K19 was negative in zone 3 atrophic
hepatocytes in venous congestion and in areas of plate
atrophy, as well as in congested or compressed sites in
NRH. Sinusoidal CD34-positivity indicating
capillarization accompanied K7 immunoexpression.
Masson trichrome revealed sinusoidal fibrosis to be
restricted in atrophic areas, usually mild and in 7 cases
focally dense. αSMA expression expanded beyond K7-
positive areas. Ki67 was negative in K7-positive
hepatocytes. Conclusion: Ischemic parenchymal changes
are characterized by hepatocyte K7 immunoexpression,
sinusoidal capillarization, HSC activation and lack of
cellular proliferation, indicating an early reaction of the
major liver parenchyma cellular components creating a
more resistant microenvironment. These phenotypic
alterations may prove valuable in the discrimination of
ischemic liver lesions.
publication.page.subject
Citation
Histology and Histopathology, Vol.31, nº10, (2016)
item.page.embargo
Ir a Estadísticas
Este ítem está sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by-nc-nd/4.0/