Publication: lmmunohistochemical expression of Retinoblastoma gene product (Rb), p53
protein, MDM2, c-erbB-2, HLA-DR and proliferation
indices in human urinary bladder carcinoma
Authors
Loachim, E. ; Charchanti, A. ; Stavropoulos, N.E. ; Skopelitou, A. ; Athanassiou, E.D. ; Agnantis, N.J.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Archival biopsy specimens from transitional
cell bladder cancers (n=88) were analysed immunohistochemically
for the expression of the retinoblastoma
(Rb) gene protein, p53, mdm2, c-erbB-2, HLA-DR
antigen and proliferation indices. An altered nuclear
expression of Rb, p53 and mdm2 was observed in
55.2%, 33.3% and 18.2% of tumors respectively.
Cytoplasmic membrane immunoreactivity (>25% tumor
cells) for c-erbB-2 was detected in 14.1% of tumors and
aberrant HLA-DR antigen cytoplasmic staining (>5% of
tumor cells) in 22.2% of the cases.
P53 overexpression was associated with higher
tumor grade and stage. Aberrant HLA-DR antigen
expression and PCNA were also correlated with the
grade of differentiation and tumor stage. MIBl was
statistically correlated with stage. pRb scores and HLADR
antigen expression were correlated with proliferation
activity as determined by PCNA and MIBl
immunostaining. p53 protein was also strongly
correlated with the proliferation index PCNA. A strong
correlation between PCNA and MIBl (pc0.0001) was
also found. In addition a statistically positive correlation
between p53 and HLA-DR antigen expression was
observed. Our data show that, although pRb and p53 protein expressions are not associated between them,
they may contribute to the growth fraction of the bladder
cancer. In addition, p53 and HLA-DR antigen expression
could be indicators of aggressive behavior of bladder
cancer.
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