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Review of sarcomatoid renal cell carcinoma with focus on clinical and pathobiological aspects

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dc.contributor.authorKuroda, Naotoes
dc.contributor.authorToi, M.es
dc.contributor.authorHiroi, Makoto
dc.contributor.authorEnzan, H.
dc.date.accessioned2011-06-08T09:02:52Z
dc.date.available2011-06-08T09:02:52Z
dc.date.issued2003
dc.description.abstractIn sarcomatoid renal cell carcinoma (RCC), it is generally accepted that the sarcomatoid portion is derived from metaplastic transformation of carcinoma. Sarcomatoid RCCs account for about 1-8% of all renal tumors. Macroscopically, tumors generally form encapsulated masses and show invasive growth. Sarcomatoid RCCs originate from all subtypes of RCCs, including conventional, papillary, chromophobe, and collecting duct carcinomas. With regard to the growth pattern of the sarcomatoid component, malignant fibrous histiocytomatous, fibrosarcomatous and unclassified sarcomatous patterns are frequently seen. Immunohistochemically, sarcomatoid RCCs are generally positive for AE1/AE3, epithelial membrane antigen (EMA) and vimentin and negative for desmin, actin and S-100. Little is know about genetic alterations in sarcomatoid RCCs. Further studies are therefore needed to identify the key gene involved in sarcomatoid transformation of RCCs.es
dc.formatapplication/pdfes
dc.format.extent5es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/21425
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectSarcomatoid renal cell carcinomases
dc.subjectPathologyes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleReview of sarcomatoid renal cell carcinoma with focus on clinical and pathobiological aspectses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.18, nº 2 (2003)