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P2X7 receptor-stimulation causes fever via PGE2 and IL-1beta release

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dc.contributor.authorBarbera-Cremades, Maria
dc.contributor.authorBaroja-Mazo, Alberto
dc.contributor.authorGomez, Ana I.
dc.contributor.authorMachado, Francisco
dc.contributor.authorDi Virgilio, Francesco
dc.contributor.authorPelegrín Vivancos, Pablo
dc.contributor.departmentBioquímica y Biología Molecular B e Inmunología
dc.date.accessioned2024-01-25T09:37:03Z
dc.date.available2024-01-25T09:37:03Z
dc.date.issued2012
dc.description©2012. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Submitted version of a Published Work that appeared in final form in FASEB Journal,. To access the final edited and published work see https://doi.org/10.1096/fj.12-205765es
dc.description.abstractProstaglandins (PG) are important lipid mediators involved in the development of inflammatory associated pain and fever. PGE2 is a well-established endogenous pyrogen activated by pro-inflammatory cytokine interleukin (IL)-1 . P2X7 receptors (P2X7R) expressed by inflammatory cells are stimulated by the danger signal extracellular ATP to activate the inflammasome and release IL-1 . Here we show that P2X7R activation is required for the release of PGE2 and other autacoids independent of inflammasome activation, with an ATP EC50 for PGE2 and IL-1 release of 1.58 and 1.23 mM, respectively. Furthermore, lack of P2X7R or specific antagonism of P2X7R decreased the febrile response in mice triggered after intra peritoneal (i.p.) LPS or IL-1 inoculation. Accordingly, LPS inoculation caused intraperitoneal ATP accumulation. Therefore, P2X7R antagonists emerge as novel therapeutics for the treatment for acute inflammation, pain and fever, with wider anti-inflammatory activity than currently used cyclooxygenase inhibitors.es
dc.formatapplication/pdfes
dc.format.extent50es
dc.identifier.citationFASEB Journal, volumen 26, nº 7, año 2012, páginas 2951-2962
dc.identifier.doi10.1096/fj.12-205765
dc.identifier.issn1530-6860
dc.identifier.issn0892-6638
dc.identifier.urihttp://hdl.handle.net/10201/137737
dc.languageenges
dc.publisherWileyes
dc.relationPN I+D+I 2008-2011-Instituto Salud Carlos III-FEDER (EMER07/049 y PI09/0120), Fundación Séneca (11922/PI/09), Italian Association for Cancer Research (AIRC).es
dc.relation.publisherversionhttps://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fj.12-205765es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectInflamaciónes
dc.subjectmacrófagoses
dc.subjectPirógenoes
dc.subjectBioluminiscenciaes
dc.subjectReceptor purinérgicoes
dc.subject.otherCDU::6 - Ciencias aplicadases
dc.titleP2X7 receptor-stimulation causes fever via PGE2 and IL-1beta releasees
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
relation.isAuthorOfPublication547c4c2c-d906-4e1d-ae9a-0cdb40eef6d1
relation.isAuthorOfPublication.latestForDiscovery547c4c2c-d906-4e1d-ae9a-0cdb40eef6d1
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