Publication: Androgen status and expression of glycoconjugates and lectins in the epithelial cells of the mouse ventral prostate. A glycohistochemical approach
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Date
1994
Authors
Akif, F. ; Gabius, H.J. ; Danguy, A.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
We investigated histochemically the
expression of glycans and endogenous sugar-binding
proteins (endolectins) in the ventral prostate of normal
and androgen-deprived mice. The avidin-biotinperoxidase
complex technique was used with a panel of
biotinylated lectins and neoglycoproteins, respectively,
on paraffin sections. Characteristic binding patterns
depending upon the type of lectin were observed in the
glandular epithelium and basement membranes. This
report also initiates the histochemical study of
endogenous glycan-binding proteins in this maleaccessory
sex organ. Remarkably, the endocrine status
was found to affect the distribution of lectin-reactive
determinants of glycoconjugates as well as endolectins.
The histophysiological significance of these
modifications in the glandular cells are discussed in the
light of previous biochemical findings obtained mainly
in humans and the rat.
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