Publication: Evaluation of CART-, glucagon-, and insulinimmunoreactive cells in the pancreas of an
experimental rat model of unilateral renal artery stenosis
Authors
Kasacka, I. ; Janiuk, I. ; Piotrowska, Z.
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
https://doi.org/10.14670/HH-30.445
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info:eu-repo/semantics/article
Description
Abstract
Hypertension is one of the most frequently
occurring diseases worldwide. Approximately 10% of
the population with hypertension reveal the secondary
type of hypertension. The aim of this study was to
evaluate the cells containing CART, insulin and
glucagon in the pancreas of rats with renovascular
hypertension.
An experimental model of hypertension in rats
according to Goldblatt (2K1C model of hypertension)
was used in the study. The experimental material
(pancreas) was collected in the 6th week of the study.
Cells containing CART, insulin and glucagon were
evaluated using immunohistochemical and morphometric methods. Pancreatic islet cells were evaluated
based on the number and intensity of staining.
The investigation showed an increase in the number
and immunoreactivity of CART containing cells, 6
weeks after partial unilateral ligation of the renal artery.
There was a significant decrease in the number of
glucagon-IR cells. Although intensity of staining these
cells did not change. No differences were observed in
the number and staining affinity of insulin-containing
cells.
On the basis of the study it can be stated that the
endocrine system of pancreas undergoes changes in the
course of renovascular hypertension. This may affect the
production of hormones and contribute to the
development of possible hypertension complications.
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Citation
Histology and Histopathology, Vol. 30, n.º 4 (2015)
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