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Comparative analysis of acute-phase protein profiles in cats undergoing ovariectomy: laparoscopic vs. conventional surgery in short time after procedure

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dc.contributor.authorCuervo, Belén
dc.contributor.authorSatué, Katy
dc.contributor.authorVelasco Martínez, María Gemma
dc.contributor.authorSopena, Joaquín Jesús
dc.contributor.authorCarrillo, José María
dc.contributor.authorDamiá, Elena Deborah
dc.contributor.authorChicharro, Deborah
dc.contributor.authorPeláez, Pau
dc.contributor.authorMartins, Emma
dc.contributor.authorGarcía Martínez, Juan Diego
dc.contributor.authorRubio, Mónica
dc.contributor.departmentMedicina y Cirugía Animal
dc.date.accessioned2025-01-30T11:20:45Z
dc.date.available2025-01-30T11:20:45Z
dc.date.issued2024-11-14
dc.description© 2024 by the authors. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/ This document is the Published Manuscript version of a Published Work that appeared in final form in Animals. To access the final edited and published work see https://doi.org/10.3390/ani14223274es
dc.description.abstractAcute-phase proteins (APPs) are biomarkers of systemic inflammation, which allow monitoring the response to surgery and post-operative complications. Ovariectomy (OVE) can be a useful model to evaluate surgical trauma and inflammation in feline species. The objective of this study was to evaluate and compare the acute-phase response (APR) after applying two different OVE techniques by measuring serum levels of serum amyloid A (SAA), haptoglobin (Hp), total serum proteins (TSPs), albumin (ALB), and paraoxonase-1 (PON-1) during the first 48 h post-surgery (hospital stay). Forty-two female cats were selected for elective spaying. The animals were randomly distributed into two groups: laparoscopic OVE (L-OVE) and midline OVE (M-OVE). Serum SAA, Hp, TSPs, ALB, and PON-1 were measured before surgery and 1, 6, 12, 24, and 48 h post-surgery. Unlike negative APPs such as PON-1 and ALB, SAA is the most sensitive positive APP for monitoring the inflammatory response in cats undergoing OVE following laparoscopic and conventional surgery. OVE performed in cats via both laparoscopic and midline techniques results in a significative increase in SAA levels, with early recovery, minor variations in serum total protein, and no significant changes in albumin, haptoglobin, or PON-1 over a 48-h period post-procedure. Based on SAA concentrations, the response to surgical trauma does not differ between surgical techniques.es
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dc.format.extent13es
dc.identifier.citationAnimals, 2024, Vol. 14 (22) : 3274
dc.identifier.doihttps://doi.org/10.3390/ani14223274
dc.identifier.urihttp://hdl.handle.net/10201/149750
dc.languageenges
dc.publisherMDPIes
dc.relationThis research was funded by CEU-UCH Research Group Support GIR 24/58 and the project IDOC 17/003 CEU-UCH, both affiliated with CEU Cardenal Herrera University, CEU universities.es
dc.relation.publisherversionhttps://www.mdpi.com/2076-2615/14/22/3274es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectAcute phase proteinses
dc.subjectFelinees
dc.subjectLaparoscopyes
dc.subjectOvariectomyes
dc.subjectSurgical traumaes
dc.titleComparative analysis of acute-phase protein profiles in cats undergoing ovariectomy: laparoscopic vs. conventional surgery in short time after procedurees
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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