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Exhaled volatilome analysis as a useful tool to discriminate asthma with other coexisting atopic diseases in women of childbearing age

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dc.contributor.authorSola Martínez, Rosa Alba
dc.contributor.authorLozano Terol, Gema
dc.contributor.authorGallego Jara, Julia
dc.contributor.authorMorales Bartolomé, Eva
dc.contributor.authorCantero-Cano, Esther
dc.contributor.authorSánchez-Solís de Querol, Manuel
dc.contributor.authorGarcía-Marcos Álvarez, Luis Vicente
dc.contributor.authorJiménez Guerrero, Pedro
dc.contributor.authorNoguera Velasco, José Antonio
dc.contributor.authorCánovas Díaz, Manuel
dc.contributor.authorDiego Puente, Teresa de
dc.contributor.authorNELA study group
dc.contributor.departmentBioquímica y Biología Molecular B e Inmunología
dc.contributor.departmentCirugía, Pediatría y Obstetricia y Ginecología
dc.date.accessioned2023-12-11T23:11:29Z
dc.date.available2023-12-11T23:11:29Z
dc.date.copyright © 2021 The Author(s)
dc.date.issued2021-07-05
dc.description.abstractThe prevalence of asthma is considerably high among women of childbearing age. Most asthmatic women also often have other atopic disorders. Therefore, the diferentiation between patients with atopic diseases without asthma and asthmatics with coexisting diseases is essential to avoid underdiagnosis of asthma and to design strategies to reduce symptom severity and improve quality of life of patients. Hence, we aimed for the frst time to conduct an analysis of volatile organic compounds in exhaled breath of women of childbearing age as a new approach to discriminate between asthmatics with other coexisting atopic diseases and non-asthmatics (with or without atopic diseases), which could be a helpful tool for more accurate asthma detection and monitoring using a noninvasive technique in the near future. In this study, exhaled air samples of 336 women (training set (n= 211) and validation set (n= 125)) were collected and analyzed by thermal desorption coupled with gas chromatography-mass spectrometry. ASCA (ANOVA (analysis of variance) simultaneous component analysis) and LASSO+LS (least absolute shrinkage and selection operator+ logistic regression) were employed for data analysis. Fifteen statistically signifcant models (p-value< 0.05 in permutation tests) that discriminated asthma with other coexisting atopic diseases in women of childbearing age were generated. Acetone, 2-ethyl-1-hexanol and a tetrahydroisoquinoline derivative were selected as discriminants of asthma with other coexisting atopic diseases. In addition, carbon disulfde, a tetrahydroisoquinoline derivative, 2-ethyl-1-hexanol and decane discriminated asthma disease among patients with other atopic disorders. Results of this study indicate that refned metabolomic analysis of exhaled breath allows asthma with other coexisting atopic diseases discrimination in women of reproductive age.
dc.formatapplication/pdfes_ES
dc.format.extent17
dc.identifier.citationScientific Reports (2021) 11:13823
dc.identifier.doihttps://doi.org/10.1038/s41598-021-92933-2
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/10201/136513
dc.languageenges_ES
dc.publisherSpringer Nature
dc.relationTis work was supported by grants from the Instituto de Salud Carlos III, Spanish Ministry of Science, Innovation and Universities, and Fondos FEDER (grant numbers CP14/00046, PIE15/00051, PI16/00422 and ARADyAL network RD160006), the Ministry of Science, Innovation and Universities (MCIU), the State Research Agency (AEI) and the European Regional Development Fund (FEDER), RTI2018-094393-B-C21-MCIU/AEI/FEDER, UE, and the Seneca Foundation CARM, 20786/PI/18. Rosa A. Sola-Martínez is a recipient of an FPU-PhD fellowship from the Ministry of Science, Innovation and Universities (FPU18/00545), and Gema Lozano-Terol is a recipient of a PhD fellowship from Seneca Foundation (20715/FPI/18). Eva Morales was funded by Miguel Servet Fellowships (MS14/00046 and CPII19/00019) awarded by the Instituto de Salud Carlos III (ISCIII), Spanish Ministry of Science, Innovation and Universities, and Fondos FEDER.
dc.relation.isreferencedbyED_IDENTRADA=1258
dc.relation.publisherversionhttps://www.nature.com/articles/s41598-021-92933-2
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.odsObjetivo 3: Salud
dc.titleExhaled volatilome analysis as a useful tool to discriminate asthma with other coexisting atopic diseases in women of childbearing agees_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
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