Publication:
Mdivi-1: a promising drug and its underlying mechanisms in the treatment of neurodegenerative diseases

Thumbnail Image
Files
Liu-37-505-512-2022.pdf(338.59 KB)
Date
2022
relationships.isAuthorOfPublication
relationships.isSecondaryAuthorOf
relationships.isDirectorOf
Authors
Liu, Xiaoqin ; Song, Lijuan ; Yu, Jiezhong ; Huang, Fang ; Li, Yanhua ; Ma, Cungen
item.page.secondaryauthor
item.page.director
Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
publication.page.editor
publication.page.department
DOI
https://doi.org/ 10.14670/HH-18-443
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Mitochondria are energy-producing organelles, and neurons are high energy consumption cells. Therefore, mitochondrial dysfunction is a critical factor in neurodegenerative processes. Mitochondrial division inhibitor-1 (Mdivi-1) is a small chemical inhibitor of mitochondrial division dynamin, which plays multiple roles in mitochondrial dynamics, mitochondrial autophagy, ATP production, the immune response, and Ca2+ homeostasis. Mdivi-1 inhibition of excessive mitochondrial fission exerted cytoprotective effects in neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS). Mdivi-1 changed the mRNA expression of the electron transport chain (ETC) and reduced Ca2+ overload against neuronal injury. Elucidation of the molecular mechanism of Mdivi-1 in neurodegenerative diseases will help evaluate its therapeutic potential and promote its application in clinical studies. The present article focused on the multiple effects of Mdivi-1 on mitochondrial function and its potential therapeutic effects in neurodegenerative diseases.
publication.page.subject
Mdivi-1 , Mitochondrial dysfunction , Neurodegenerative diseases
Citation
Histology and Histopathology Vol. 37, nº6 (2022)
URI
http://hdl.handle.net/10201/128555
item.page.embargo
Collections
Histology and histopathology Vol.37, nº6 (2022)
Ir a Estadísticas