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NovoMem® vs CorMatrix®: Decellularisation efficiency and extracellular matrix integrity for future vascular grafting

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dc.contributor.authorJun Wei Heng
dc.contributor.authorShalini Rajan
dc.contributor.authorNur Sabrina Zainal Abidin
dc.contributor.authorNg Min Hwei1
dc.contributor.authorNadiah Sulaiman
dc.contributor.authorAhmad Hafiz Murtadha
dc.contributor.departmentBiología Celular e Histología
dc.contributor.editorUniversidad de Murcia, Departamento de Biologia Celular e Histiologia
dc.date.accessioned2026-05-07T08:16:04Z
dc.date.available2026-05-07T08:16:04Z
dc.date.issued2026
dc.description.abstractNovoMem®, a collagen membrane derived from supercritical carbon dioxide (scCO2) decellularised porcine pericardium, is currently used as a barrier in dental bone grafts. In line with sustainable development goals, repurposing NovoMem® for vascular grafts presents a strategic opportunity. This study aims to evaluate NovoMem®'s decellularisation efficiency and extracellular matrix (ECM) preservation to assess its potential for vascular tissue engineering. The decellularisation efficiency was assessed using haematoxylin and eosin (H&E) staining and DNA quantification to confirm cellular removal and fulfilment of the proposed minimal criteria of decellularisation. ECM integrity was evaluated through collagen staining (Picrosirius red), elastin staining (Elastin van Gieson), and an insoluble collagen assay to measure total collagen. NovoMem® showed significantly reduced cellular content while preserving ECM architecture. The decellularised tissue had minimal residual DNA and retained its collagen framework. Compared with CorMatrix®, a commercially available chemically decellularised cardiac patch from porcine small intestinal submucosa (SIS) that has been repurposed for vascular grafts, NovoMem® exhibited superior decellularisation efficiency with comparable ECM preservation. NovoMem® also possesses biocompatibility, supporting mesenchymal stem cell growth. In conclusion, NovoMem® has minimal cellular content with preserved structural integrity, thus suggesting it as an effective vascular graft that could integrate with host tissues with minimal risk of alloreactivity, potentially improving graft efficacy and long-term patency.
dc.formatapplication/pdf
dc.format.extent12
dc.identifier.doihttps://doi.org/10.14670/HH-25-009
dc.identifier.eissn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/230241
dc.languageeng
dc.relationSin financiación externa a la Universidad
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectTissue engineering
dc.subjectDecellularised scaffold
dc.subjectSmall-diameter vascular graft
dc.subjectCardiac patch
dc.subjectCoronary artery disease
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleNovoMem® vs CorMatrix®: Decellularisation efficiency and extracellular matrix integrity for future vascular grafting
dc.typeinfo:eu-repo/semantics/article
dspace.entity.typePublication
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Histology and histopathology, Vol.41, Nº5, (2026)