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Human skin reconstruct models: A new application for studies of melanocyte and melanoma biology

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dc.contributor.authorBerking, C.es
dc.contributor.authorHerlyn, M.es
dc.date.accessioned2011-05-11T10:56:17Z
dc.date.available2011-05-11T10:56:17Z
dc.date.issued2001
dc.description.abstractStudies of melanocyte and melanoma biology using monocultures of cells are limited because of culture-induced morphology changes and expression of genes related to growth, migration, and invasion, which do not reflect the in situ phenotype of normal melanocytes, nevus cells, or melanoma cells from biologically early progression stages. The development of organotypic cultures of human skin, in which culture artifacts are greatly diminished and cell-matrix and cellcell interactions between different cell types can be investigated in a three-dimensional system, has opened a new era for melanoma research. Long-term in vivo studies, especially important for melanomagenesis and melanoma metastasis have become possible through grafting of skin reconstructs to immuno.deficient laboratory animals. In this review, principles and different methods of skin reconstruction are introduced with focus on the application for pigment cell biologyes
dc.formatapplication/pdfes
dc.format.extent6es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/20677
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectMelanomaes
dc.subjectMelanocytees
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología::616.5 - Piel. Dermatología clínicaes
dc.titleHuman skin reconstruct models: A new application for studies of melanocyte and melanoma biologyes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.16, nº 2 (2001)