Publication: Determinants of axonal regeneration
Authors
Frisén, J.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Axons often regrow to their targets and lost
functions may be restored after an injury in the
peripheral nervous system. In contrast, axonal
regeneration is generally very limited after injuries in the
central nervous system, and functional impairment is
usually permanent. The regenerative capacity depends
on intrinsic neuronal factors as weil as the interaction of
neurons with other cells. Glial cells may, in different
situations, either support or inhibit axonal growth. This
review discusses the molecular mechanisms that are
involved in promoting and inhibiting axonal regeneration
in the nervous system after injuries.
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Citation
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