Publication: Effects of alcohol and aging on the cingular (area 24) and frontal (area 6) cortical areas of the mouse
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Date
1998
Authors
Marrero-Gordillo, N. ; Pérez-Delgado, M. del M. ; Carmona-Calero, E. ; Pérez-González, H. ; Ferres Torres, R. ; Castañeyra Perdomo, A.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
We have studied the morphometric changes
of the neurons of the cingular area 24 and frontal area 6
of the mouse, produced by age andlor chronic alcohol
intake. The parameters analyzed were nuclear area of
these cortical neurons and cellular density (celllneuropil
coefficient). Wc dctccted a decrease in the number of
neurons with age in practically al1 layers of the control
animals. In the animals that chronically ingested the
alcoholic solution, we also detected a decrease in the
number of neurons with age, but only in layer V of the
frontal cortex and in layer VI of the cingular area 24.
The comparison between the control and the alcoholic
group showed that alcohol intake caused an incrcasc in
the nuclear area of the neurons in layer 11-111 of the
frontal cortcx at 180 days, while in the cingular cortex
the increase in nuclear area of its neurons was
significative at 180 days in layer 11-111 and at 35 and 180
days in layers V and VI. We think that these changes are
the expression of the neurona1 plasticity in both cortical
areas in response to the alcohol exposure.
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