Publication: The role of proteoglycans in the reactive stroma on tumor growth and progression
Authors
Coulson-Thomas, Yvette May ; Gesteira Ferreira, Tarsis ; Lawrence Norton, Andrew ; W-Y Kao, Winston ; Bonciani Nader, Helena ; Coulson-Thomas, Vivien Jane
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
https://doi.org/10.14670/HH-30.33
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info:eu-repo/semantics/article
Description
Abstract
The stroma surrounding tumors can either
restrict or promote tumor growth and progression, and
both the cellular and non-cellular components of the
stroma play an active role. The cellular components in
the surrounding stroma include tumor-associated
fibroblasts, host tissue cells and immune cells. The noncellular components, which form the extracellular matrix
(ECM) scaffold, include proteoglycans, collagen,
proteinases, growth factors and cytokines. For
tumorigenesis to occur it is necessary for tumor cells to
modify the surrounding stroma. Tumor cells have
mechanisms for achieving this, such as co-opting
fibroblasts and modifying the ECM they produce,
degrading the surrounding ECM and/or synthesizing a
favorable ECM to support invasion. Proteoglycans are
an important component of the ECM and play an active
role in tumor growth and progression. The expression
and glycosylation patterns of proteoglycans are altered
in the stroma surrounding tumors and these molecules
may support or restrict tumor growth and progression
depending on the type and stage of tumor. In the present
review we discuss the difference between the tumor
promoting and restricting stromal reactions surrounding
tumors and the role proteoglycans play.
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Citation
Histology and Histopathology, Vol. 30, n.º 1 (2015)
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