Ovarian cancer: insights into genetics and pathogeny

Liliac, Ludmila; Amălinei, Cornelia; Balan, Raluca; Grigoraş, Adriana; Căruntu, Irina-Draga

Publication:
Ovarian cancer: insights into genetics and pathogeny

dc.contributor.author	Liliac, Ludmila
dc.contributor.author	Amălinei, Cornelia
dc.contributor.author	Balan, Raluca
dc.contributor.author	Grigoraş, Adriana
dc.contributor.author	Căruntu, Irina-Draga
dc.date.accessioned	2017-03-13T15:15:04Z
dc.date.available	2017-03-13T15:15:04Z
dc.date.issued	2012
dc.description.abstract	Starting from the information on ovarian cancer provided by the mainstream publications, we construct a review focusing on the following issues: (i) the genetic profile, (ii) the role of the epithelial-mesenchymal transition in the acquirement of malignant features, (iii) the controversial hypothesis regarding the origin, and (iv) the involvement of the immune system in the tumoral microenvironment. Advances in the decipherment at the genetic level in the pathogenic mechanisms progressively lead to the idea of a genetic signature for the ovarian cancer. Moreover, the complementary approaches oriented towards the decryption of the intrinsic structure of the expressed molecules and, implicitly, the development of proteomics open new perspectives for an early diagnosis and an appropriate treatment. The research on the epithelial-mesenchymal transition (mainly those exploring the signaling pathways responsible for the switch between the loss of the epithelial characteristics and the gain of a mesenchymal cell phenotype, with results in the amplification of differentiation, motility and tumoral invasion) allow a deeper understanding of the complex pathogenic mechanism which governs ovarian carcinogenesis. The classic conception of ovarian cancer pathogeny, based on the role of the ovarian surface epithelium, is currently reconsidered, and a novel hypothesis is formulated, which supports direct involvement of the Fallopian tubes for the serous type. Although recent research suggests the implication of immune/inflammatory cells by specific mechanisms in ovarian cancer pathogenesis, there is yet reliable evidence concerning their modality of direct action and/or modulation of tumoral growth. Thus, ovarian carcinogenesis remains a research challenge, due to still numerous unknown factors involved in the malignant transformation sequences, originating from the genetic-molecular alterations and reflected by cellular and tissue expression patterns.	es
dc.format	application/pdf	es
dc.format.extent	13	es
dc.identifier.citation	Histology and Histopatholy, Volume 27, number 6 (June), 2012
dc.identifier.issn	1699-5848
dc.identifier.issn	0213-3911
dc.identifier.uri	http://hdl.handle.net/10201/52447
dc.language	eng	es
dc.publisher	F. Hernandez y JuanF. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología.	es
dc.rights	info:eu-repo/semantics/openAccess	es
dc.subject	Ovarian cancer	es
dc.subject	Pathogenesis	es
dc.subject.other	CDU::5 - Ciencias puras y naturales::57 - Biología	es
dc.title	Ovarian cancer: insights into genetics and pathogeny	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es