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Shared and differential retinal responses against optic nerve injury and ocular hypertension

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dc.contributor.authorVidal Sanz, Manuel
dc.contributor.authorGalindo Romero, Caridad
dc.contributor.authorValiente-Soriano, Francisco J.
dc.contributor.authorNadal-Nicolás, Francisco Manuel
dc.contributor.authorOrtín-Martínez, Arturo
dc.contributor.authorRovere, Giuseppe
dc.contributor.authorSalinas Navarro, Manuel Ángel
dc.contributor.authorLucas Ruiz, Fernando
dc.contributor.authorSánchez-Migallón, María C.
dc.contributor.authorSobrado Calvo, Paloma
dc.contributor.authorAvilés Trigueros, Marcelino
dc.contributor.authorVillegas Pérez, Maria Paz
dc.contributor.authorAgudo Barriuso, Marta
dc.contributor.departmentOftalmología, Optometría, Otorrinolaringología y Anatomía Patológica
dc.contributor.otherFacultad de Medicina
dc.date.accessioned2026-01-27T19:45:43Z
dc.date.available2026-01-27T19:45:43Z
dc.date.copyright© 2017 Vidal-Sanz, Galindo-Romero, Valiente-Soriano, Nadal-Nicolás, Ortín-Martínez, Rovere, Salinas-Navarro, Lucas-Ruiz, Sánchez-Migallon, Sobrado Calvo, Avilés-Trigueros, Villegas-Pérez and Agudo-Barriuso.
dc.date.issued2017-04-26
dc.description.abstractGlaucoma, one of the leading causes of blindness worldwide, affects primarily retinal ganglion cells (RGCs) and their axons. The pathophysiology of glaucoma is not fully understood, but it is currently believed that damage to RGC axons at the optic nerve head plays a major role. Rodent models to study glaucoma include those that mimic either ocular hypertension or optic nerve injury. Here we review the anatomical loss of the general population of RGCs (that express Brn3a; Brn3a+RGCs) and of the intrinsically photosensitive RGCs (that express melanopsin; m+RGCs) after chronic (LP-OHT) or acute (A-OHT) ocular hypertension and after complete intraorbital optic nerve transection (ONT) or crush (ONC). Our studies show that all of these insults trigger RGC death. Compared to Brn3a+RGCs, m+RGCs are more resilient to ONT, ONC, and A-OHT but not to LP-OHT. There are differences in the course of RGC loss both between these RGC types and among injuries. An important difference between the damage caused by ocular hypertension or optic nerve injury appears in the outer retina. Both axotomy and LP-OHT induce selective loss of RGCs but LP-OHT also induces a protracted loss of cone photoreceptors. This review outlines our current understanding of the anatomical changes occurring in rodent models of glaucoma and discusses the advantages of each one and their translational value.
dc.formatapplication/pdf
dc.format.extent14
dc.identifier.citationFront Neurosci. 2017 Apr 26;11:235
dc.identifier.doihttps://doi.org/10.3389/fnins.2017.00235
dc.identifier.eissn1662-453X
dc.identifier.issn1662-4548
dc.identifier.urihttp://hdl.handle.net/10201/195450
dc.languageeng
dc.publisherFrontiers Media SA.
dc.relationFinancial support for these studies was obtained from Fundación Séneca, Agencia de Ciencia y Tecnología Región de Murcia (19881/GERM/15), and the Spanish Ministry of Economy and Competitiveness, Instituto de Salud Carlos III, Fondo Europeo de Desarrollo Regional “Una Manera de Hacer Europa” (SAF2015-67643-P, PI16/00380; RD16/0008/0026, PI16/00031).
dc.relation.publisherversionhttps://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2017.00235/full
dc.rightsAttribution 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectBrn3a retinal ganglion cells
dc.subjectAcute ocular hypertension
dc.subjectAxotomy
dc.subjectChronic ocular hypertension
dc.subjectCone photoreceptors
dc.subjectGlaucoma
dc.subjectMelanopsin retinal ganglion cells
dc.subjectRetinal nerve fiber layer
dc.subject.odsObjetivo 3: Salud
dc.titleShared and differential retinal responses against optic nerve injury and ocular hypertension
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
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