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Anogenital distance, a biomarker of prenatal androgen exposure Is associated with prostate cancer severity

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dc.contributor.authorMaldonado-Cárceles, Ana B.
dc.contributor.authorSánchez-Rodríguez, Carlos
dc.contributor.authorVera-Porras, Eva M.
dc.contributor.authorOñate-Celdrán, Julián
dc.contributor.authorSamper Mateo, Paula
dc.contributor.authorGarcía Escudero, Damián
dc.contributor.authorTorres-Roca, Marcos
dc.contributor.authorMartínez Díaz, Francisco
dc.contributor.authorMendiola, Jaime
dc.contributor.authorTorres Cantero, Alberto Manuel
dc.contributor.authorArense Gonzalo, Julián Jesús
dc.contributor.departmentOftalmología, Optometría, Otorrinolaringología y Anatomía Patológica
dc.date.accessioned2024-12-12T12:15:52Z
dc.date.available2024-12-12T12:15:52Z
dc.date.issued2016-11-16
dc.description© 2016 Wiley Periodicals, Inc. This document is the Published version of a Published Work that appeared in final form in Prostate. To access the final edited and published work see https://doi.org/10.1002/pros.23279
dc.description.abstractBACKGROUND. Anogenital distance (AGD), the distance from the centre of the anus to the genitals, is a sexually dimorphic phenotype in mammals. Experimental studies have shown that AGD is a biomarker of prenatal androgen exposure during the masculinisation period of development. The aim of this study is to assess the relationship between anogenital distance (AGD), as an indirect marker of prenatal hormonal environment, and prostate cancer (PCa) severity. MATERIALS. We conducted a cross-sectional study with a total of 120 PCa patients with confirmed biopsy of the tumour from April 2007 to July 2015. Two variants of the anogenital distance were assessed, from the anus to the posterior base of the scrotum (AGDAS) and to the cephalad insertion of the penis (AGDAP). We compared differences in groups to evaluate the association between AGD measurements and severity of the preoperative biopsy and clinical scores. RESULTS. Longer AGDAS was significantly associated with the highest Gleason score (P = 0.015) and D'Amico nomogram (P = 0.048). In contrast, no statistical differences were found in the AGDAP and severity of the preoperative biopsy. CONCLUSIONS. These findings are consistent with the hypothesis that a higher prenatal androgen exposure is associated with higher severity of PCa. Prostate.es
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dc.format.extent6es
dc.identifier.citationThe Prostate 77:406–411 (2017)
dc.identifier.doihttps://doi.org/10.1002/pros.23279
dc.identifier.issnPrint: 1097-0045
dc.identifier.issnElectronic: 0270-4137
dc.identifier.urihttp://hdl.handle.net/10201/147389
dc.languageenges
dc.publisherWiley
dc.relationSin financiación externa a la Universidades
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/10.1002/pros.23279
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectAnogenital distancees
dc.subjectD’Amico nomogrames
dc.subjectGleason scorees
dc.subjectPreoperative PSAes
dc.subjectProstate canceres
dc.titleAnogenital distance, a biomarker of prenatal androgen exposure Is associated with prostate cancer severityes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
relation.isAuthorOfPublicationbd30abc2-f9f7-4d31-99e6-f05b5b0c0a8e
relation.isAuthorOfPublication.latestForDiscoverybd30abc2-f9f7-4d31-99e6-f05b5b0c0a8e
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