Publication: Human megakaryocyte ploidy
Authors
Kobayashi, Y. ; Kondo, M.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
We reviewed the literature concerning the
history of determination of the ploidy of human megakaryocytes
and its relationship with diseases. The ploidy
of rabbit megakaryocytes was analyzed by microspectrophotometry
in 1964, and the analysis of the ploidy in
human megakaryocytes was first performed in 1968.
Presently, microphotometry and flow cytometry are the
primary methods for the evaluation of the ploidy, but
they have their merits and demerits. In the ploidy of
human megakaryocytes, a peak has often been reported
at 16N in healthy individuals, and the next peaks have
been observed at 32N and 8N. The results of ploidy
analyses have been reported by many investigators to be
comparable between patients with idiopathic thrombocytopenic
purpura and normal subjects, but various shifts
of the peaks have also been documented. The ploidy is
often reported to shift to a larger ploidy class in polycythemia
vera and essential thrombocythemia, but it has
invariably been reported to shift to a smaller class in
chronic myelogenous leukemia. In reactive thrombocytosis,
the ploidy pattern was reported to be the same as
that in normal individuals by some investigators but to
shift to a larger ploidy by others. These differences are
considered to be due to heterogeneity of the subjects. In
myelodysplastic syndrome, the ploidy shifts mostly to a
smaller class, but it may show various patterns. We also
reviewed the ploidy in other rare hematological
disorders, the relationships of the ploidy with diabetes
mellitus and atherosclerotic disorders, and its changes in
the ontogeny. Details of the mechanism of polyploidization
and its biological significance remain unknown,
and further advances in the studies of these topics are
anticipated.
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