Publication: Up-regulation of CMKLR1 in endometriosis and its relationship with inflammatory responses
Authors
Zhang, Zhe ; Ding, Yumei ; Li, Junjie ; Su, Shan
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/10.14670/HH-18-523
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info:eu-repo/semantics/article
Description
Abstract
Inflammation plays a critical role in the
pathogenesis of endometriosis. We aimed to study the
proinflammatory effect of Chemerin chemokine-like
receptor 1 (CMKLR1) in patients with endometriosis.
Sixty patients with endometriosis and 50 healthy
controls were recruited in this study for the collection of
endometrial samples and peritoneal fluid. The
expression levels of CMKLR1, IL-6, MCP-1, and TNFα in peritoneal fluid and endometrial tissues were
detected by ELISA, qRT-PCR, and immunohistochemical staining. Human endometrial stromal cells
(HESCs) were used to measure the Chemerin-induced
CMKLR1 activation and inflammatory responses.
CMKLR1 level was significantly up-regulated in
peritoneal fluid and endometrial tissues in patients with
endometriosis. Interestingly, CMKLR1 overexpression
positively correlated with pro-inflammatory cytokines
and chemokine in both peritoneal fluid and ectopic
endometrium. Chemerin treatment increased the
expression of CMKLR1, and aggravated inflammatory
responses in HESCs. CMKLR1 is up-regulated in
peritoneal fluid and endometrial tissues, and promotes
the inflammatory responses in of endometriosis.
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Citation
Histology and Histopathology Vol. 38, nº3 (2023)
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