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N-Cadherin, ADAM-10 and Aquaporin 1 expression in lung tissue exposed to fluoroedenite fibers: an immunohistochemical study

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dc.contributor.authorMusumeci, Giuseppe
dc.contributor.authorLoreto, Carla
dc.contributor.authorSzychlinska, Marta Anna
dc.contributor.authorImbesi, Rosa
dc.contributor.authorRapisarda, Venerando
dc.contributor.authorAiello, Flavia Concetta
dc.contributor.authorCastorina, Sergio
dc.contributor.authorCastrogiovanni, Paola
dc.date.accessioned2020-09-22T13:25:40Z
dc.date.available2020-09-22T13:25:40Z
dc.date.issued2015
dc.description.abstractFluoro-edenite (FE) fibers are similar to other amphibole asbestos fibers. The scientific relevance of FE is due to its ability to lead to chronic inflammation and carcinogenesis in lung tissue shown after its inhalation. These fibers stimulate aberrant host cell proliferation and induce the release of cytokines, growth factors, reactive oxygen and nitrite species, which results in DNA damage. In previous studies, we showed that FE induces functional modifications in sheep and human lung fibroblasts and alveolar epithelial cells, where the overexpression of several molecules probably involved in pathological cellular mechanisms induced by FE exposition have been detected. However, the mechanisms of cellular and molecular toxicity and the cellular response to FE fibers are still not well known. N-cadherin, ADAM-10 and AQP1 are molecules involved in carcinogenesis and in inflammatory process. In this study we analyzed, through immunohistochemistry, their expression in the lung tissue of sheep exposed to FE. Our results showed different patterns of immunolabeling for N-cadherin, ADAM-10 and AQP1. N-cadherin and ADAM-10 were more expressed in FE exposed lung tissue, when compared with the control. On the contrary, AQP1 was more expressed in non exposed lung tissue. These results suggest that NCadherin, ADAM-10 and AQP1 are probably involved in different pathological processes induced by FE fiber exposition. The aim of the study was to better understand the mechanisms of cellular and molecular toxicity and of cellular response to FE fibers in order to identify, in the future, a possible therapeutic intervention in cases of FE-associated pathogenesis.es
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dc.format.extent13es
dc.identifier.citationHistology and histopathology, Vol. 30, nº 8 (2015)
dc.identifier.doihttps://doi.org/10.14670/HH-11-603
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/96344
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histologíaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectFluoro-edenite fiberses
dc.subjectN-cadherines
dc.subjectADAM10es
dc.subjectAQP1es
dc.subjectLung tissuees
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citologíaes
dc.titleN-Cadherin, ADAM-10 and Aquaporin 1 expression in lung tissue exposed to fluoroedenite fibers: an immunohistochemical studyes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.30, nº8 (2015)