Publication: Ischemic culture of dental pulp-derived
cells is a useful model in which to investigate
mechanisms of post-ischemic tissue recovery
Authors
Agata, Hideki ; Sumita, Yoshinori ; Asahina, Izumi ; Tojo, Arinobu ; Kagami, Hideaki
item.page.secondaryauthor
item.page.director
Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Dental pulp is a soft tissue characterized by
unique regenerative properties. It is located in the center
of each tooth, and is surrounded by hard tissue (dentin).
Vascular access is limited to a small foramen at the root
apex. Because of this anatomical limitation, dental pulp
can easily lose its blood supply, causing the tissue to
become ischemic. This occurs, for example, when a
tooth is dislocated by traumatic injury or is subjected to
inflammation. Since ischemia is caused by a critical
shortage of oxygen and nutrients, ischemic damage is
usually irreversible, even when the ischemic event is
transient. However, unlike ischemia-sensitive organs
such as the brain and heart, dental pulp is relatively
ischemia-resistant, and recovers from ischemic injury by
regenerating damaged tissue. The mechanisms by which
this regeneration occurs are poorly understood, but are
being investigated in cell culture models that mimic in
vivo ischemic conditions using a combination of hypoxia
and nutrient deprivation. Here, we review the use of
ischemic cell culture to investigate the mechanisms of
post-ischemic dental pulp tissue recovery.
publication.page.subject
Citation
Histology and Histopathology, vol. 28, nº 8 (2013)
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.