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Transcriptional regulation of the Oct4 gene, a master gene for pluripotency

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dc.contributor.authorKellner, Stevenes
dc.contributor.authorKikyo, Nobuakies
dc.date.accessioned2015-01-20T12:06:47Z
dc.date.available2015-01-20T12:06:47Z
dc.date.issued2010
dc.description.abstractOct4 is one of the most importanttranscription factors required to maintain anundifferentiated state (self-renewal) and pluripotency ofhuman and mouse embryonic stem (ES) cells as well asearly embryonic cells. In addition, Oct4 is the onlyknown transcription factor that has to be exogenouslyintroduced into differentiated cells to make inducedpluripotent stem (iPS) cells. Therefore, it is of greatimportance to understand howOct4transcription isregulated in ES cells and embryos and how it becomesactivated during iPS cell formation. In this article, wewill review the regulation of the mouse Oct4gene fromthe viewpoint of DNA methylation, binding of orphannuclear receptors, histone modifications and synergisticeffects with other pluripotency factors. We will also raiseseveral key questions that need to be addressed in futurework to improve our understanding of Oct4generegulation and its essential role in self-renewal andpluripotency.en_EN
dc.formatapplication/pdfes
dc.format.extent8es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/42588
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectEpigeneticses
dc.subjectPluripotencyes
dc.subject.other616 - Patología. Medicina clínica. Oncologíaes
dc.titleTranscriptional regulation of the Oct4 gene, a master gene for pluripotencyes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.25, nº3 (2010)