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The influence of aneurysm morphology on the volume of hemorrhage after rupture

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dc.contributor.authorMunarriz, Pablo M.
dc.contributor.authorNavarro Main, Blanca
dc.contributor.authorAlén, José F.
dc.contributor.authorJiménez Roldán, Luis
dc.contributor.authorCastaño León, Ana María
dc.contributor.authorMoreno Gómez, Luis Miguel
dc.contributor.authorParedes, Igor
dc.contributor.authorGarcía Pérez, Daniel
dc.contributor.authorPanero, Irene
dc.contributor.authorEiriz Fernández, Carla
dc.contributor.authorEsteban Sinovas, Olga
dc.contributor.authorBárcena, Eduardo
dc.contributor.authorGómez, Pedro A.
dc.contributor.authorLagares, Alfonso
dc.contributor.departmentFarmacología
dc.contributor.otherFacultades de la UMU::Facultad de Medicina
dc.date.accessioned2026-02-20T07:01:59Z
dc.date.available2026-02-20T07:01:59Z
dc.date.copyright© AANS 2022, except where prohibited by US copyright law
dc.date.issued2021-09-17
dc.description.abstractOBJECTIVE Factors determining the risk of rupture of intracranial aneurysms have been extensively studied; however, little attention is paid to variables influencing the volume of bleeding after rupture. In this study the authors aimed to evaluate the impact of aneurysm morphological variables on the amount of hemorrhage. METHODS This was a retrospective cohort analysis of a prospectively collected data set of 116 patients presenting at a single center with subarachnoid hemorrhage due to aneurysmal rupture. A volumetric assessment of the total hemorrhage volume was performed from the initial noncontrast CT. Aneurysms were segmented and reproduced from the initial CT angiography study, and morphology indexes were calculated with a computer-assisted approach. Clinical and demographic characteristics of the patients were included in the study. Factors influencing the volume of hemorrhage were explored with univariate correlations, multiple linear regression analysis, and graphical probabilistic modeling. RESULTS The univariate analysis demonstrated that several of the morphological variables but only the patient’s age from the clinical-demographic variables correlated (p < 0.05) with the volume of bleeding. Nine morphological variables correlated positively (absolute height, perpendicular height, maximum width, sac surface area, sac volume, size ratio, bottleneck factor, neck-to-vessel ratio, and width-to-vessel ratio) and two correlated negatively (parent vessel average diameter and the aneurysm angle). After multivariate analysis, only the aneurysm size ratio (p < 0.001) and the patient’s age (p = 0.023) remained statistically significant. The graphical probabilistic model confirmed the size ratio and the patient’s age as the variables most related to the total hemorrhage volume. CONCLUSIONS A greater aneurysm size ratio and an older patient age are likely to entail a greater volume of bleeding after subarachnoid hemorrhage.
dc.formatapplication/pdf
dc.format.extent9
dc.identifier.citationJournal of Neurosurgery, 2022, Vol. 136, Issue 4, pp. 1015–1023
dc.identifier.doihttps://doi.org/10.3171/2021.3.JNS21293
dc.identifier.eissn1933-0693
dc.identifier.issn0022-3085
dc.identifier.urihttp://hdl.handle.net/10201/208682
dc.languageeng
dc.publisherAmerican Association of Neurological Surgeons (AANS)
dc.relationSin financiación externa a la Universidad
dc.relation.publisherversionhttps://thejns.org/view/journals/j-neurosurg/136/4/article-p1015.xml
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectSubarachnoid hemorrhage
dc.subjectComputational geometry
dc.subjectImage segmentation
dc.subjectVolumetric analysis
dc.subjectAneurysm morphology
dc.subjectVascular disorder
dc.subjectIntracranial aneurysm
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleThe influence of aneurysm morphology on the volume of hemorrhage after rupture
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublicationes
relation.isAuthorOfPublication2f2500a1-1b27-4420-820c-db8c16e79afd
relation.isAuthorOfPublication.latestForDiscovery2f2500a1-1b27-4420-820c-db8c16e79afd
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