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Effectiveness of the botulinum toxin for treating sialorrhea in patients with Parkinson’s disease: a systematic review

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dc.contributor.authorRuiz Roca, Juan Antonio
dc.contributor.authorPons-Fuster López, Eduardo
dc.contributor.authorLópez Jornet, María Pía
dc.contributor.departmentDermatología, Estomatología, Radiología y Medicina Física
dc.contributor.otherFacultades de la UMU::Facultad de Medicina
dc.date.accessioned2026-03-25T07:37:18Z
dc.date.available2026-03-25T07:37:18Z
dc.date.copyright© 2019 by the authors.
dc.date.issued2019-03-06
dc.description.abstractThe main objective was to assess the efficacy of botulinum toxin-based treatment for sialorrhea in adult patients with Parkinson’s disease. The search was performed by using the Medline-PubMed, EMBASE and Cochrane Library databases from January 2000–December 2017, in English/Spanish in patients with Parkinson’s disease and sialorrhea. The methodological quality of trials was carried out by following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) criteria and the Newcastle–Ottawa Scale (NOS). Finally, a total of 21 articles were identified as fulfilling the inclusion criteria. There is no consensus regarding the site of injection of the toxin (single or multiple points), toxin dose or follow-up period. In all cases there was a reduction of sialorrhea. Treatment safety increases with the use of ultrasonography. Effects approximately occur at one week post-injection and for 3–5 months. Botulinum toxin is an effective therapeutic strategy or option in treating sialorrhea in adult patients with Parkinson’s disease. More studies with a better design, larger samples and a longer follow-up period are required to confirm these data.
dc.formatapplication/pdf
dc.format.extent12
dc.identifier.citationJ. Clin. Med. 2019, 8, 317;
dc.identifier.doihttps://doi.org/10.3390/jcm8030317
dc.identifier.eissn2077-0383
dc.identifier.urihttp://hdl.handle.net/10201/222661
dc.languageeng
dc.publisherMDPI
dc.relationSin financiación externa a la Universidad
dc.relation.publisherversionhttps://www.mdpi.com/2077-0383/8/3/317
dc.rightsAttribution 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectSialorrhea
dc.subjectDrooling
dc.subjectParkinson's disease
dc.subjectBotulinum toxin
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleEffectiveness of the botulinum toxin for treating sialorrhea in patients with Parkinson’s disease: a systematic review
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublicationes
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relation.isAuthorOfPublication772daa73-9c3b-4afc-8cd1-5a95adb03d88
relation.isAuthorOfPublication4f429718-4d7c-4637-a758-1f1024672669
relation.isAuthorOfPublication.latestForDiscoverye24de175-ae66-43d3-adbd-c15f9022e2b6
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