Publication: Lymphangiogenesis and its role in cancer
Authors
Al-Rawi, M.A.A. ; Mansel, R.E. ; Jiang, W.G.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
In many tumour types, lymphatic vasculature
serves as a major route for tumour metastasis. The
dissemination of malignant cells to the regional lymph
nodes is an early step in the progression of many solid
tumours and is an important determinant of prognosis.
Lymphangiogenesis (formation of new lymphatic
vessels) is thought to be crucial for cancer cells to
metastasise to the regional lymph nodes. However
research in this important process has been neglected
largely due to the lack of molecular markers specific to
the lymphatic endothelium. Recently, several specific
markers have been identified including LYVE-1,
podoplanin and prox-1. Although the biology of
lymphangiogeneis, particularly its regulation, is still far
from clear, it is now well established that tumours are
lymphangiogenic i.e. they could induce the generation of
their own lymphatics and metastasise to the regional
lymph nodes. It is thought that the interruption of the
main signalling pathways involved in this process could
help to prevent lymphatic spread of many tumours.
Furthermore, understanding the molecular mechanisms
in lymphangiogenesis might help to develop new
therapeutic strategies against cancer lymphatic spread.
Here, we reviewed the literature in regards to the biology
of lymphangiogenesis, its molecular regulation,
lymphatic markers and the significance in human solid
tumours.
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