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Therapeutic effects of an azaphenothiazine derivative in mouse experimental colitis

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dc.contributor.authorArtym, Jolanta
dc.contributor.authorKocięba, Maja
dc.contributor.authorZaczyńska, Ewa
dc.contributor.authorZimecki, Michał
dc.contributor.authorKałas, Wojciech
dc.contributor.authorStrządała, Leon
dc.contributor.authorPawlak, Alicja
dc.contributor.authorJeleń, Małgorzata
dc.contributor.authorMorak Młodawska, Beata
dc.contributor.authorPluta, Krystian
dc.contributor.authorKaleta Kuratewicz, Katarzyna
dc.contributor.authorMadej, Jan P.
dc.contributor.authorKuropka, Piotr
dc.contributor.authorKuryszko, Jan
dc.date.accessioned2022-11-28T12:41:12Z
dc.date.available2022-11-28T12:41:12Z
dc.date.issued2020
dc.description.abstractPhenothiazines represent a class of compounds of potential therapeutic utility. In this report we evaluated therapeutic value of an azaphenothiazine derivative, 6-acetylaminobutyl-9-chloroquino[3,2- b]benzo[1,4]thiazine (QBT), given intragastrically, in the model of dextran sodium sulfate-induced colitis in C57BL/6 mice using 5-aminosalicylic acid (5-ASA) as a reference drug. Colitis symptoms such as body weight loss, diarrhea and hematochezia (blood in stool) were observed and registered and disease activity index (DAI) was calculated. In addition, weight and cell numbers in the lymphatic organs and histological parameters of the colon wall were analyzed. The effects of QBT on viability of colon epithelial cell lines were also determined. We showed that weight and cell number of draining mesenteric lymph nodes were lower in mice treated with QBT in comparison to their control counterparts. The number of thymocytes, drastically reduced in control mice, was elevated in mice treated with the compounds with a significant effect of 5-ASA. In addition, an abnormal composition of blood cell types was partially corrected in these groups. Histological analysis of the colon revealed that the pathological changes were partially normalized by QBT and even to a higher degree by 5-ASA. In conclusion we demonstrated a therapeutic efficacy of the compound in amelioration of local and systemic pathological changes associated with chemically-induced colitis in mice. A possible mechanism of action of the compound is discussed.es
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dc.format.extent9es
dc.identifier.citationHistology and Histopathology Vol. 35, nº7 (2020)
dc.identifier.doihttps://doi.org/10.14670/HH-18-192
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/126027
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAzaphenothiazineses
dc.subject5-ASAes
dc.subjectColitises
dc.subjectDextran sodium sulfatees
dc.subjectMicees
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleTherapeutic effects of an azaphenothiazine derivative in mouse experimental colitises
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.35, nº7 (2020)