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Number and spatial distribution of intrinsically photosensitive retinal ganglion cells in the adult albino rat

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dc.contributor.authorGalindo Romero, Caridad
dc.contributor.authorJiménez López, Manuel
dc.contributor.authorGarcía Ayuso, Diego
dc.contributor.authorSalinas Navarro, Manuel Ángel
dc.contributor.authorNadal-Nicolás, Francisco Manuel
dc.contributor.authorAgudo Barriuso, Marta
dc.contributor.authorVillegas Pérez, Maria Paz
dc.contributor.authorAvilés Trigueros, Marcelino
dc.contributor.authorVidal Sanz, Manuel
dc.contributor.departmentOftalmología, Optometría, Otorrinolaringología y Anatomía Patológica
dc.contributor.otherFacultades de la UMU::Facultad de Medicina
dc.date.accessioned2026-01-27T08:42:45Z
dc.date.available2026-01-27T08:42:45Z
dc.date.copyright © 2012 Elsevier Ltd.
dc.date.issued2013-01-04
dc.description.abstractIntrinsically photosensitive retinal ganglion cells (ipRGCs) respond directly to light and are responsible of the synchronization of the circadian rhythm with the photic stimulus and for the pupillary light reflex. To quantify the total population of rat-ipRGCs and to assess their spatial distribution we have developed an automated routine and used neighbour maps. Moreover, in all analysed retinas we have studied the general population of RGCs - identified by their Brn3a expression - and the population of ipRGCs - identified by melanopsin immunodetection - thus allowing the co-analysis of their topography. Our results show that the total mean number ± standard deviation of ipRGCs in the albino rat is 2047 ± 309. Their distribution in the retina seems to be complementary to that of Brn3a(+)RGCs, being denser in the periphery, especially in the superior retina where their highest densities are found in the temporal quadrant, above the visual streak. In addition, by tracing the retinas from both superior colliculi, we have also determined that 90.62% of the ipRGC project to these central targets.
dc.formatapplication/pdf
dc.format.extent10
dc.identifier.citationExp Eye Res. 2013 Mar;108:84-93.
dc.identifier.doihttps://doi.org/10.1016/j.exer.2012.12.010
dc.identifier.issn0014-4835
dc.identifier.urihttp://hdl.handle.net/10201/194229
dc.languageeng
dc.publisherElsevier
dc.relationThis workhasbeenfundedby:SpanishMinistryofEconomyand Competitiviness and ISCIII-FEDER “Una manera de hacer Europa”: PI10/00187, PI10/01496, Fundación Séneca 04446/GERM/07; Spanish Ministry of Education and Science SAF-22010-10385 and Red Temática de Investigación Cooperativa en Oftalmología RD07/ 0062/0001.
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0014483512003727
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectMelanopsin
dc.subjectBrn3a
dc.subjectRetrograde axonal tracing
dc.subjectNeighbour map
dc.subjectAutomated quantification
dc.subjectRetinal ganglion cells
dc.subjectAdult albino rat
dc.subject.odsObjetivo 3: Salud
dc.titleNumber and spatial distribution of intrinsically photosensitive retinal ganglion cells in the adult albino rat
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
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