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Mast cell chymase: an indispensable instrument in the pathological symphony of idiopathic pulmonary fibrosis?

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dc.contributor.authorKosanovic, Djuro
dc.contributor.authorDaha, Bhola Kumar
dc.contributor.authorWygrecka, Malgorzata
dc.contributor.authorReiss, Irwin
dc.contributor.authorGünther, Andreas
dc.contributor.authorGhofrani, Ardeschir
dc.contributor.authorWeissmann, , Norbert
dc.contributor.authorGrimminger, Friedrich
dc.contributor.authorSeeger, Werner
dc.contributor.authorSchermuly, Ralph Theo
dc.contributor.authorBanat, Gamal-Andre
dc.date.accessioned2018-05-16T09:25:03Z
dc.date.available2018-05-16T09:25:03Z
dc.date.issued2013
dc.description.abstractIdiopathic pulmonary fibrosis (IPF) is a chronic, progressive and fatal lung disease with no known etiology and treatment options. The hallmarks of the histopathology, which is characteristic of usual interstitial pneumonia (UIP) pattern, include interstitial fibrosis, honeycomb changes and fibroblast foci that develop owing to fibroblast proliferation and excessive matrix deposition. Although the complete pathomechanism is not yet understood, several molecular culprits, including transforming growth factor (TGF)-ß, Angiotensin (Ang) II, endothelin (ET)-1, matrix metalloproteinases (MMPs) and cytokines have been identified. IPF is increasingly believed to be an epithelial-driven disease; however, the literature does support an implication of altered immune response and inflammatory processes in the onset or progression of the disease. Mast cells (MCs) are multifunctional tissue resident cells involved in the inflammatory and immune response. An increasing body of evidence suggests a role of MCs and their mediator chymase in the pathology of IPF. With regard to the underlying mechanisms, it is conceivable that MC chymase may function via activation or processing of factors such as proteases, cytokines and growth factors. In this review, we will discuss how MC chymase is linked to and can potentially contribute to the development of IPF. Moreover, the findings from animal model studies will be discussed to highlight the chymase inhibitors as a promising strategy for the treatment of pulmonary fibrosis.es
dc.formatapplication/pdfes
dc.format.extent9es
dc.identifier.citationHistology and Histopathology, vol. 28, nº 6, (2013)
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/58460
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histologíaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectMast cellses
dc.subjectChymasees
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleMast cell chymase: an indispensable instrument in the pathological symphony of idiopathic pulmonary fibrosis?es
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.28, nº 6 (2013)