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Expression of adhesion molecules and mucins in human and rhesus macaque gastrointestinal epithelial cells

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dc.contributor.authorZhang, Hong-Yu
dc.contributor.authorChang, Hong
dc.contributor.authorFan, Xiao-Na
dc.contributor.authorZhang, Kui-Dong
dc.contributor.authorYu, Lu
dc.contributor.authorCao, Yi
dc.date.accessioned2016-05-02T16:23:50Z
dc.date.available2016-05-02T16:23:50Z
dc.date.issued2011
dc.description.abstractEpithelial junctions and mucins play key roles in the gastrointestinal mucosal barrier, and their alterations are associated with numerous diseases, including carcinomas. The systematic expression of adhesion molecules and mucins in normal and malignant human gastrointestinal cells was investigated in this study. In normal human gastrointestinal cells, zonula occludens-1 (ZO-1), α-catenin, ß-catenin, γ-catenin and desmoglein-2 (DSG2) were located in the cytoplasmic membranes, whereas symplekin stained in the nuclei. ZO-1, the three catenins, and DSG2 were observed in the gastric and colorectal carcinomas with reduced and heterogeneous expression and with abnormal distribution. Symplekin was detected in the nuclei of tumor cells in most tumors but not observed in some others. The immunohistochemical results for ZO-1 and symplekin on the tissues were consistent with the data for the cultured cells obtained by immunocytochemical staining and Western blot analysis. MUC1 was not stained in the normal gastrointestinal cells without periodate oxidation, but it was strongly labeled in the malignant gastrointestinal cells. MUC2 was detected in the normal and malignant gastrointestinal cells without the periodate treatment. These findings indicate that alterations in the expression of the epithelial junctions and mucins are associated with the malignant transformation of gastrointestinal cells. In addition, the gastrointestinal epithelial cells of rhesus macaques expressed these adhesion molecules and mucins, as did the human cells, suggesting that the rhesus monkey is a suitable experimental animal model for research on adhesion molecules and mucins.es
dc.formatapplication/pdfes
dc.format.extent9es
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/49499
dc.languageenges
dc.publisherF. Hernández y J.F. Madrid. Murcia: Universidad de Murcia, Departamento de Biología Celular e Histología.es
dc.relation.ispartofHistology and histopathology, Vol. 26, nº11 (2011)es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectAdhesion moleculees
dc.subjectMucinses
dc.subject.other61 - Medicinaes
dc.titleExpression of adhesion molecules and mucins in human and rhesus macaque gastrointestinal epithelial cellses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.26,nº11 (2011)