Publication: Experimental thioacetamide-induced cirrhosis of the liver
Authors
Muñoz Torres, E. ; Paz-Bouza, J.I. ; López Bravo, A. ; Abad Hernández, M.M. ; Carrascal Marino, E.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Hepatic cirrhosis is a complex disease in
which several biological, biochemical and chemical
alterations are combined, none of these alone being
sufficient for diagnosis. The morphological characteristics
of the final stages of cirrhosis are well known,
but the initial lesions and intermediate stages still have
not been fully clarified.
An experimental model of hepatic cirrhosis by
chronic administration over 30 weeks of thioacetamide
(50 mglkg twice weekly) to female Wistar rats has been
produced. In a macroscopic, microscopic and ultrastructural
study. The different lesions that appeared were
evaluated according to the dose of the toxic agent administered
up, until hepatic cirrhosis was finally installed;
this was after 60 doses of the toxic agent (30 weeks).
Discussion is made of the different types of administration
and the doses employed to obtain a suitable
survival rate for these cases; in our experiments this
was 95%.
It has been demonstrated in both human and experimental
pathology that once the disease itself has been
installed, currently there is no rational or useful
treatment for it. A beneficial effect has been demonstrated
for certain substances, improving the initial and
intermediate lesions. so we conclude by stating that it is
necessary to further study the hepatic lesions preceeding
cirrhosis. Knowledge of these lesions could form the
basis for establishing a useful and rational therapy for
such cases.
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