Publication: lron binding proteins in gallbladder carcinomas An immunocytochemical investigation
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Date
1997
Authors
Tuccari, G. ; Rossiello, R. ; Barresi, G.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
By immunohistochemistry, the presence of
major iron-binding proteins (lactoferrin, transferrin,
ferritin) has been investigated in adenocarcinomas (27
cases), adenosquamous carcinoma (1 case), undifferentiated
sarcomatoid carcinoma (1 case) and
mucinous adenocarcinomas (3 cases) of the gallbladder;
10 samples of chronic lithyasic cholecystitis, 4
adenomyomas and 6 tubulo-villous adenomas have also
been studied.
In a variable share of adenocarcinomas, a positive
immunoreactivity for iron-binding antisera was
encountered in the cytoplasm, while tubulo-villous
adenomas, adenomyomas and the normal epithelium of
the gallbladder were generally unreactive. In carcinomatous
lesions, the staining intensity was variable
between different cases or individual tumour cells.
The production of these iron-binding proteins in the
gallbladder carcinoma in itself could be related to a
greater availability of iron for metabolic processes in
the neoplastic cell; alternatively, the cytoplasmic
localization of these substances in carcinomatous
elements may be a consequence of a defective or
impaired function of iron-binding receptors with a
modified degree of transmembranous iron transfer.
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