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Elevated expression of G protein-coupled receptor 30 (GPR30) is associated with poor prognosis in patients with uterine cervical adenocarcinoma

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dc.contributor.authorTagami, Yohei
dc.contributor.authorIno, Yoshihiko
dc.contributor.authorAkimoto, Taishi
dc.contributor.authorTakasawa, Akira
dc.contributor.authorTakasawa, Kumi
dc.contributor.authorAoyama, Tomoyuki
dc.contributor.authorUeda, Asako
dc.contributor.authorOta, Misaki
dc.contributor.authorMagara, Kazufumi
dc.contributor.authorMurata, Masaki
dc.contributor.authorHasegawa, Tadashi
dc.contributor.authorSaito, Tsuyoshi
dc.contributor.authorSawada, Norimasa
dc.contributor.authorOsanai, Makoto
dc.date.accessioned2022-11-14T16:43:34Z
dc.date.available2022-11-14T16:43:34Z
dc.date.issued2020
dc.description.abstractUterine cervical adenocarcinoma has a worse prognosis than that of squamous cell carcinoma and useful diagnostic and prognostic markers are needed. Estrogen is one of the key regulators of several cancers, however, the estrogen signaling has not been focused on in cervical adenocarcinoma. Here, we shows expression profile of classical estrogen receptor (ER) and a novel membrane type estrogen receptor, G protein-coupled receptor 30 (GPR30), in surgical specimens (n=53). GPR30 was strongly expressed on the cell membrane and in the cytoplasm in adenocarcinoma in situ (AIS) and adenocarcinoma, and its expression was especially strong at the invasion front in most of the cases of GPR30-positive adenocarcinoma. Nuclear staining of ER was strong in non-neoplastic glands, whereas it was almost absent in most of the AIS and adenocarcinoma cases. There was a weak but statistically significant negative correlation between immunoreactivity of GPR30 and that of ER in cervical AIS and adenocarcinoma lesions (Spearman’s correlation, r=- 0.324, p=0.017). ROC curve analysis revealed that immunoreactivity of GPR30 successfully distinguished neoplasms from non-neoplastic glands with high specificity (100%) and sensitivity (75.5%). GPR30 positivity was significantly correlated with histological type (p=0.009), tumor diameter (p=0.003), tumor size (p<0.001), lymphovascular infiltration (p=0.005) and UICC stage (p<0.001). ER expression was correlated only with tumor factor (p=0.047). GPR30-high patients had poor prognosis with a significantly shorter overall survival (OS) period (p=0.0309). GPR30 expression is a potential diagnostic and prognostic marker.es
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dc.format.extent9es
dc.identifier.citationHistology and Histopathology Vol. 35, nÂş4 (2020)
dc.identifier.doihttps://doi.org/10.14670/HH-18-157
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/125571
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiaciĂłn externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectCervical adenocarcinomaes
dc.subjectEstrogen receptores
dc.subjectG protein-coupled receptor 30 (GPR30)es
dc.subjectG protein-coupled estrogen receptor 1 (GPER1)es
dc.subjectInvasion frontes
dc.subjectPrognosises
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - PatologĂ­a. Medicina clĂ­nica. OncologĂ­aes
dc.titleElevated expression of G protein-coupled receptor 30 (GPR30) is associated with poor prognosis in patients with uterine cervical adenocarcinomaes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.35, nÂş4 (2020)