Publication: Morphological changes in the rat
carotid body 1, 2, 4, and 8 weeks after the
termination of chronically hypocapnic hypoxia
Authors
Kusakabe, T. ; Hirakawa, H. ; Oikawa, S. ; Matsuda, H. ; Kawakami, T. ; Takenaka, T. ; Hayashida, Y.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Morphological changes in the rat carotid
bodies 1, 2, 4, and 8 weeks after the termination of
chronically hypocapnic hypoxia (10% O2 for 8 weeks)
were examined by means of morphometry and
immunohistochemistry. The rat carotid bodies after 8
weeks of hypoxic exposure were enlarged several fold
with vascular expansion. The carotid bodies 1 and 2
weeks after the termination of 8 weeks of hypoxic
exposure were diminished in size, although their
diameter remained larger than the normoxic controls.
The expanded vasculature in chronically hypoxic carotid
bodies returned to the normoxic control state. In the
carotid bodies 1 week after the termination of chronic
hypoxia, the density of NPY fibers was remarkably
increased and that of VIP fibers was dramatically
decreased in comparison with the density in chronically
hypoxic carotid bodies. In the carotid bodies 2 and 4
weeks after the termination of hypoxia, the density of SP
and CGRP fibers was gradually increased. In the carotid
bodies 8 weeks after the termination of hypoxia, the
appearance of the carotid body returned to a nearly
normoxic state, and the density of SP, CGRP, VIP, and
NPY fibers also recovered to that of normoxic controls.
These results suggest that the morphological changes in
the recovering carotid bodies start at a relatively early
period after the termination of chronic hypoxia, and a
part of these processes may be under the control of
peptidergic innervation.
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