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Cocaine abuse and its impact on the thymus and spleen

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dc.contributor.authorAki, Toshihiko
dc.contributor.authorUnuma, Kana
dc.contributor.departmentBiología Celular e Histologíaes
dc.date.accessioned2025-09-04T08:28:02Z
dc.date.available2025-09-04T08:28:02Z
dc.date.issued2025
dc.description.abstractCocaine is a psychostimulant abused worldwide. Its pharmacotoxicological properties are derived mainly from its impact on the neurotransmission of sympathomimetic nerves. Cocaine enhances and prolongs the neurotransmission of monoamines, such as dopamine, serotonin, and adrenaline, which are responsible not only for cocaine’s euphoric effects, but also its cardiovascular toxicity. In addition to these effects on central as well as peripheral nerves, immunosuppression is also implicated in cocaine toxicity. The thymus and spleen are lymphoid organs that are essential in lymphocyte maturation and erythrocyte homeostasis. Reductions in thymus and spleen size, which are observed under both physiological and pathological conditions, are known as thymic involution and splenic contraction, respectively. These phenomena are also observed in experimental animal models of binge cocaine abuse. In this brief review, we describe the mechanisms of cocaine toxicity, thymic involution, and splenic contraction, followed by discussions about the possible role of the latter two phenomena in cocaine intoxication.es
dc.formatapplication/pdfes
dc.format.extent8es
dc.identifier.citationHistology and Histopathology Vol. 40, nº09 (2025)
dc.identifier.doihttps://doi.org/10.14670/HH-18-904
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/158147
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectCocainees
dc.subjectThymuses
dc.subjectSpleenes
dc.subjectImmune systemes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleCocaine abuse and its impact on the thymus and spleenes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.40, nº9 (2025)