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The effect of delays in cancer surgery due to the COVID-19 pandemic on cancer resectability and postoperative mortality in different tumor entities

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dc.contributor.authorGarcía Pérez, Daniel
dc.contributor.authorStengler, Antonia L.
dc.contributor.authorKleeff, Jörg
dc.contributor.authorRieder, Lisa
dc.contributor.authorGlasbey, James C.
dc.contributor.authorBhangu, Aneel A.
dc.contributor.authorHarrison, Ewen M.
dc.contributor.authorRonellenfitsch, Ulrich
dc.contributor.authorCovidSurg Collaborative
dc.contributor.departmentFarmacología
dc.date.accessioned2026-05-19T07:19:15Z
dc.date.available2026-05-19T07:19:15Z
dc.date.copyright© 2026 The Author(s)
dc.date.issued2026-05-09
dc.description.abstractBackground: During the COVID-19 pandemic, prioritization of COVID-19 patients led to delays in oncological surgery, potentially impacting patient outcomes. This analysis examines the effects of surgical delays in various tumor entities on resectability and postoperative mortality. Methods: Data from the COVIDSurg Cancer Collaborative, an international prospective cohort study with 19,676 patients, collected between March 26, 2020, and September 16, 2020, were analyzed. Postoperative mortality and complete resection (R0) were the outcomes, with tumor entity, stage and delay to surgery as key exposures. Results: 17,486 patients underwent surgery during the study period, at a median time of three weeks after decision to operate (IQR = 4). 172 (1.0%) patients died within 30 days postoperatively. 15,143 (90.5%) patients had an R0 resection, 1352 (8.1%) an R1 resection and 230 (1.4%) had an R2 resection. Postoperative mortality was highest for oesophageal cancer (3.9%) and UICC stage IV (1.5%). For the overall population, there was no association between delay to surgery and resectability. There was an association between delay to surgery and postoperative mortality (p < 0.001), with the highest 30-day postoperative mortality observed for operations within two weeks following surgical decision. Conclusion: Tumor resectability and postoperative mortality in oncological surgeries are influenced by various factors. During the COVID-19 pandemic, moderate delays in surgeries were observed, with differences across tumor types, UICC stages and regions. While no tangible effects on resectability were found, postoperative mortality was higher after a shorter delay to surgery.
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dc.format.extent13
dc.identifier.citationDiscover Oncology (2026) 17:716
dc.identifier.doihttps://doi.org/10.1007/s12672-026-04430-5
dc.identifier.eissn2730-6011
dc.identifier.urihttp://hdl.handle.net/10201/232821
dc.languageeng
dc.publisherSpringer, Discover
dc.relationThe paper was prepared as part of the “Collaboration for Pandemic Preparedness” (CoPrep) project, which is funded by the Ministry of Science, Energy, Climate Change and Environment of the State of Saxony-Anhalt, Germany. This project aims to enhance pandemic preparedness in Saxony-Anhalt in light of the COVID-19 pandemic and seeks to develop strategies for better preparedness for future pandemic situations in Saxony-Anhalt and across Germany. The State of Saxony-Anhalt had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
dc.relation.publisherversionhttps://link.springer.com/article/10.1007/s12672-026-04430-5
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectCancer operations
dc.subjectCOVID-19 pandemic
dc.subjectDelay to surgery
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleThe effect of delays in cancer surgery due to the COVID-19 pandemic on cancer resectability and postoperative mortality in different tumor entities
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublicationes
relation.isAuthorOfPublication2f2500a1-1b27-4420-820c-db8c16e79afd
relation.isAuthorOfPublication.latestForDiscovery2f2500a1-1b27-4420-820c-db8c16e79afd
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