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Concentrations of bisphenol-A in adults from the general population: A systematic review and meta-analysis.

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dc.contributor.authorColorado Yohar, Sandra M.
dc.contributor.authorCastillo González, Ana C.
dc.contributor.authorSánchez Meca, Julio
dc.contributor.authorRubio Aparicio, María
dc.contributor.authorSánchez Rodríguez, Diego
dc.contributor.authorSalamanca Fernández, Elena
dc.contributor.authorArdanaz, Eva
dc.contributor.authorAmiano, Pilar
dc.contributor.authorFernández, Mariana M.
dc.contributor.authorMendiola Olivares, Jaime
dc.contributor.authorNavarro Mateu, Fernando
dc.contributor.authorChirlaque López, María Dolores
dc.contributor.departmentCiencias Sociosanitarias
dc.date.accessioned2024-07-11T11:06:52Z
dc.date.available2024-07-11T11:06:52Z
dc.date.issued2021-06-25
dc.description© 2021 Elsevier Inc. This document is the Published version of a Published Work that appeared in final form in Science of the Total Environment. To access the final edited and published work see https://doi.org/10.1016/j.scitotenv.2021.145755
dc.description.abstractBackground: Human bisphenol-A (BPA) exposure has been linked to adverse health effects even at low doses, which may be of potential public health concern. Objective: To summarize BPA concentrations in general human population and their variability according to sex, geographic area, and analytical method. Methods: Systematic review and meta-analysis of studies reporting BPA concentrations in adult human populations. Separate meta-analyses of median values were carried out for BPA in serum, creatinine-adjusted urinary BPA, and unadjusted urinary BPA concentrations using a random-effects model. Cochran's Q-statistic, I2 index, 95% prediction intervals (PIs), between-studies standard deviation (τ), and forest plots were applied to verify study heterogeneity. Sensitivity and subgroup analyses and weighted ANOVAs and meta-regressions were conducted. Funnel plots and Egger's tests were used to examine publication bias. Results: Fifteen studieswere included in themeta-analysis, totaling 28,353 participants. BPAwas detected in over 90% of participants. The pooled creatinine-adjusted urinary BPA concentrationwas 1.76 μg/g (95% PI: 0.79–2.73), with individual estimates ranging between 1.20 and 2.41. The pooled estimate for unadjusted urinary BPA was 1.91 μg/l (95% PI: 0–3.97), ranging between 0.81 and 3.50, while the pooled estimate for serum BPA was 1.75 μg/l (95% PI: 0–10.58), ranging between 0.34 and 3.76. No differences were found by sex, geographic area or analytical technique. Larger sample sizeswere associatedwith lower BPA concentrations. Therewas large heterogeneity across studies, whereas data for urinary BPA levels suggested a publication bias affecting research in low exposed populations. Conclusion: This first meta-analysis of human BPA concentrations highlights a widespread population exposure to BPA. Although there was high heterogeneity across studies, the expected range of estimated human BPA concentrations suggests that potential health risks are unlikely. Further studies are warranted to better characterize the epidemiology of human BPA exposure, accounting for ethnic, geographic, individual and environmental variability.es
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dc.identifier.citationScience of The Total Environment, 2021, Vol. 775: 145755
dc.identifier.doihttps://doi.org/10.1016/j.scitotenv.2021.145755
dc.identifier.issnPrint: 0048-9697
dc.identifier.issnElectronic: 1879-1026
dc.identifier.urihttp://hdl.handle.net/10201/143012
dc.languageenges
dc.publisherElsevier
dc.relationThis work was supported by the AECC-Junta Provincial de Murcia (FFIS-2006), and received partial funding from the Murcia Biomedical Research Institute (IMIB)-FFIS and the Spanish Biomedical Research Network Center (CIBER) (BOE-A-2020-6018).es
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0048969721008226
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.titleConcentrations of bisphenol-A in adults from the general population: A systematic review and meta-analysis.es
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
relation.isAuthorOfPublicationd574b2ee-b5f0-4552-b9e9-a7622381f3f6
relation.isAuthorOfPublication.latestForDiscoveryd574b2ee-b5f0-4552-b9e9-a7622381f3f6
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