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Cotton rats (Sigmodon hispidus) possess pharyngeal pouch remnants originating from different primordia

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dc.contributor.authorNakamura, Teppei
dc.contributor.authorIchii, Osamu
dc.contributor.authorIrie, Takao
dc.contributor.authorMizoguchi, Tatsuya
dc.contributor.authorShinohara, Akio
dc.contributor.authorKouguchi, Hirokazu
dc.contributor.authorSunden, Yuji
dc.contributor.authorOtsuka Kanazawa, Saori
dc.contributor.authorAli Elewa, Yaser Hosny
dc.contributor.authorKoshimoto, Chihiro
dc.contributor.authorNagasaki, Ken Ichi
dc.contributor.authorKon, Yasuhiro
dc.date.accessioned2022-04-25T10:25:27Z
dc.date.available2022-04-25T10:25:27Z
dc.date.issued2018
dc.description.abstractPharyngeal pouches in mammals develop into specific derivatives. If the differentiation of the pharyngeal pouches is anomalous, their remnants can result in cysts, sinuses, and fistulae in the differentiated organs or around the neck. In the present study, we found several pharyngeal pouch remnants, such as cystic structures in thymus and parathyroid gland and fossulae extended from the piriform fossa, in the inbred cotton rats maintained at Hokkaido Institute of Public Health (HIS/Hiph) and University of Miyazaki (HIS/Mz). In HIS/Hiph, the fossulae extended from the apex of the piriform fossa into the thyroid glands and were lined with stratified squamous and cuboidal epithelium. Calcitonin-positive C-cells were present within their epithelium in HIS/Hiph. In contrast, the fossulae of HIS/Mz ran outside the thyroid glands toward the parathyroid glands; they were lined with columnar ciliated epithelium and a few goblet cells, but had no Ccells, which was consistent with the cystic structures in the thymus and the parathyroid gland. These results indicated that the fossulae were a remnant of the ultimobranchial body in HIS/Hiph and of the thymopharyngeal duct in HIS/Mz. Thus, the fossulae of the piriform fossa resembled the piriform sinus fistula in human. In conclusion, cotton rats frequently possessed pharyngeal pouch remnants, including the piriform sinus fistula, and therefore, might serve as a novel model to elucidate the mechanisms of pharyngeal pouch development.es
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dc.format.extent11es
dc.identifier.citationHistology and Histopathology, Vol.33, nÂş6, (2018)
dc.identifier.doiDOI: 10.14670/HH-11-946
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/119092
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de BiologĂ­a Celular e HistologĂ­aes
dc.relationSin financiaciĂłn externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectCotton rates
dc.subjectPharyngeal pouch remnantes
dc.subjectThymopharyngeal ductes
dc.subjectUltimobranchial bodyes
dc.subjectPiriform sinus fistulaes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - PatologĂ­a. Medicina clĂ­nica. OncologĂ­aes
dc.titleCotton rats (Sigmodon hispidus) possess pharyngeal pouch remnants originating from different primordiaes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.33, nÂş6 (2018)