Publication:
Exposure to second-hand cigarette smoke exacerbates the progression of osteoarthritis in a surgical induced murine model

Thumbnail Image
Files
Rose-36-347-353-2021.pdf(3.42 MB)
Date
2021
relationships.isAuthorOfPublication
relationships.isSecondaryAuthorOf
relationships.isDirectorOf
Authors
Rose, Brandon J. ; Weyand, Jeffery A. ; Liu, Brady ; Smith, Jacob F. ; Perez, Brian R. ; Clark, J. Christian ; Goodman, Michael ; Budge, Kelsey M. Hirschi ; Eggett, Dennis L. ; Arroyo, Juan A. ; Reynolds, Paul R. ; Kooyman, David L.
item.page.secondaryauthor
item.page.director
Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
publication.page.editor
publication.page.department
DOI
https://doi.org/10.14670/HH-18-311
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Osteoarthritis (OA), formerly understood to be a result of passive wear, is now known to be associated with chronic inflammation. Cigarette smoking promotes systemic inflammation and has been implicated in increased joint OA incidence in some studies, though the recent observational data on the association are contradictory. We hypothesize that second-hand smoke (SHS) treatment will increase the incidence of OA in a mouse model that has been subjected to a surgical destabilization of the medial meniscus (DMM). To test this hypothesis, we applied either SHS treatment or room air (RA) to mice for 28 days post-DMM surgery. Histopathology findings indicated that the knees of SHS mice exhibited more severe OA than their control counterparts. Increased expression of matrix metalloprotease-13 (MMP-13), an important extracellular protease known to degrade articular cartilage, and nuclear factor kappa-light-chainenhancer of activated B cells (NF-κB), an intracellular effector of inflammatory pathways, were observed in the SHS group. These findings provide greater understanding and evidence for a detrimental role of cigarette smoke on OA progression and systemic inflammation.
publication.page.subject
Second-hand smoke , Osteoarthritis , DMM
Citation
Histology and Histopathology Vol. 36, nº3 (2021)
URI
http://hdl.handle.net/10201/127016
item.page.embargo
Collections
Histology and histopathology Vol.36, nº3 (2021)
Ir a Estadísticas