Publication: In vitro effects of hormones and autacoids on the hydrogen peroxide production and the morphology
of endotoxin-activated rat peritoneal macrophages
Authors
Kondomerkos, D.J. ; Kalamidas, Stefanos ; Kotoulas, Othon B.
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Peritoneal macrophages activated in vitro by
endotoxin exhibit alterations of their capability to
produce hydrogen peroxide after phorbol ester
stimulation when certain hormones or autacoids are
present in the culture medium. They also show
morphological changes, mainly concerning cell size and
nuclear appearance. Agents known to increase the
intracellular levels of cyclic AMP, e.g. adrenalin and
PGE2 reduce the hydrogen peroxide production. Insulin,
which is known to decrease cyclic AMP levels, produces
opposite results. Agents postulated to act via
phospholipase C, e.g. serotonin, augment the production
of hydrogen peroxide. We assume that this form of
modulation may represent a regulatory mechanism of
macrophage activation.
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.