Publication:
3D model of the maternal-fetal interface: challenges, recent advances and beyond

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dc.contributor.authorPassaponti, Sofia
dc.contributor.authorLuongo, Francesca Paola
dc.contributor.authorIetta, Francesca
dc.contributor.authorLuddi, Alice
dc.contributor.authorPiombon, Paola
dc.date.accessioned2023-09-07T08:42:11Z
dc.date.available2023-09-07T08:42:11Z
dc.date.issued2023
dc.description.abstractEmbryo implantation is a complex and highly coordinated process that involves an intricate network of factors establishing intimate contact at the maternal-fetal interface. Knowledge of the human implantation process is compromised by both ethical issues, which do not allow the study of this process in vivo, and by the accuracy and reproducibility of in vitro models of human endometrium. Effective and reliable embryo implantation models are, therefore, necessary to mimic the molecular event cascade that occurs in vivo. 3D models are considered a new step to foster precision medicine and an advanced tool for the study of endometrial biology, endometrium associated diseases and to understand the complex mechanisms surrounding endometrium-embryo crosstalk. In this review we explore the various methods by which 3D cultures of endometrium and trophoblast can be created, exploring targets and applications of these in vitro models.es
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dc.format.extent15es
dc.identifier.citationHistology and Histopathology Vol. 38, nº8 (2023)
dc.identifier.doihttps://doi.org/10.14670/HH-18-584
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/133707
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologia
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject3D in vitro modeles
dc.subjectEmbryoes
dc.subjectEndometriumes
dc.subjectEndometrial receptivityes
dc.subjectOrganoidses
dc.subjectEmbryoidses
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología::616.1 - Patología del sistema circulatorio, de los vasos sanguíneos. Transtornos cardiovasculareses
dc.title3D model of the maternal-fetal interface: challenges, recent advances and beyondes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.38, nº8 (2023)